Short-term control of hepatic lipogenesis by insulin
TLDR
Evidence that insulin acutely affects carbohydrate and lipid metabolism in isolated rat hepatocytes is presented and a coherent picture emerges of the concerted mechanism by which insulin sets the stage for lipogenesis in the hepatocyte.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1980-11-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Lipogenesis & Insulin.read more
Citations
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In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose.
TL;DR: The fasted-to-fed transition of hepatic carbohydrate and lipid metabolism can be accomplished in vitro over a time frame similar to that operative in vivo, and the requirement for insulin in the reversal of the fasting state of liver metabolism in vivo can best be explained by its ability to offset the catabolic actions of glucagon.
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The effects of insulin and glucagon on the release of triacylglycerols by isolated rat hepatocytes are mere reflections of the hormonal effects on the rate of triacylglycerol synthesis
TL;DR: It is concluded that the effects of insulin and glucagon on the overall process of triacylglycerol secretion are reflections of the hormone-determined rate of Triacyl Glycerol synthesis.
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Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes.
TL;DR: Findings suggest that insulin-induced increases in DAG may lead to increases in protein kinase C activity, and may explain some of the insulin-like effects of phorbol esters and vasopressin on hepatocyte metabolism.
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Short‐term regulation of glycolysis by insulin and dexamethasone in cultured rat hepatocytes
TL;DR: The stimulation of glycolysis by insulin was investigated in monolayer cultures of adult rat hepatocytes and dexamethasone acted both as a long-term and short-term modulator, and the stimulatory effects of insulin may in part be attributed to the activated pyruvate kinase.
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Short-term inhibition of fatty acid biosynthesis in isolated hepatocytes by mono-aromatic compounds
Anton C. Beynen,Math J.H. Geelen +1 more
TL;DR: It is proposed that all of the drugs exert an inhibitory action at the level of acetyl-CoA carboxylase, the enzyme generally considered to catalyse the rate-limiting step in hepatic fatty acid synthesis.
References
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Pyruvate dehydrogenase and the hormonal regulation of fat synthesis in mammalian tissues.
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Acute effects of insulin on glycerol phosphate acyl transferase activity, ketogenesis and serum free fatty acid concentration in perfused rat liver
TL;DR: In isolated adipocytes insulin increases the synthesis of triacylglycerol and in vitro adipocyte glycerol phosphate acyltransferase and long-chain fatty acyl CoA synthetase activities have been shown to increase as a result of insulin treatment.
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Re-evaluation of lipogenesis from dietary glucose carbon in liver and carcass of mice.
TL;DR: These studies provide direct evidence in mice of the major contribution that dietary carbohydrate makes, especially in the liver, to the synthesis of fatty acids, and it is shown that lipogenic inhibition and activation are most marked in liver and greater for glucose than for non-glucose-carbon.
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Levels of cyclic 3′-5′-adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon
TL;DR: Under conditions of short-term stimulation of lipogenesis by insulin in maintenance cultures of hepatocytes from starved rats, basal levels of cyclic 3′-5′-adenosine monophosphate (cAMP) are invariant and glucagon signals increased levels of cAMP and severely diminishes lipogenesis.
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Specific role of glucose in rapid lipogenic activation in vivo.
N. Baker,R. J. Huebotter +1 more
TL;DR: The flux of endogenous glucose C to total lipid fatty acids (TLFA) in mice fasted for 1 day was compared with the minimal average flux of exogenous dietary glucose to TLFA during a 40-min period after the ingestion of various glucose-rich test meals by previously fasted mice.