Journal ArticleDOI
Sonic hedgehog in CNS development: one signal, multiple outputs.
Elisa Martí,Paola Bovolenta +1 more
TLDR
A more precise understanding of the molecular mechanisms that underlie the different responses to SHH signalling is the next step in the study of this molecule and its role in the regulation of neural development.About:
This article is published in Trends in Neurosciences.The article was published on 2002-02-01. It has received 259 citations till now. The article focuses on the topics: Sonic hedgehog & Hedgehog Family.read more
Citations
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Hedgehog: functions and mechanisms
Markku Varjosalo,Jussi Taipale +1 more
TL;DR: This review focuses broadly on the current understanding of Hh signaling, from mechanisms of action to cellular and developmental functions, and the role of HH in the pathogenesis of human disease and the possibilities for therapeutic intervention.
Journal ArticleDOI
Adult neurogenesis: from precursors to network and physiology.
TL;DR: An overview of the current knowledge on adult neurogenesis and its functional relevance for the adult brain is proposed and a growing list of epigenetic factors that display a specificity of action depending on the neurogenic site under consideration has been identified.
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Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling
Balázs Gereben,Ann Marie Zavacki,Scott Ribich,Brian W. Kim,Stephen A. Huang,Warner S. Simonides,Anikó Zeöld,Antonio C. Bianco,Antonio C. Bianco +8 more
TL;DR: It seems clear that deiodinases play a much broader role than once thought, with great ramifications for the control of thyroid hormone signaling during vertebrate development and metamorphosis, as well as injury response, tissue repair, hypothalamic function, and energy homeostasis in adults.
Journal ArticleDOI
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.
TL;DR: Results provide evidence that Shh, acting via Smo, is a midline-derived chemoattractant for commissural axons and show that a morphogen can also act as an axonal chemoATTractant.
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The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death
TL;DR: It is proposed that in mammals, autophagy may be involved in specific cytosolic rearrangements needed for proliferation, death, and differentiation during embryogenesis and postnatal development.
References
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Journal ArticleDOI
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chin Chiang,Ying Litingtung,Eric Lee,Keith E. Young,Jeffrey L Corden,Heiner Westphal,Philip A. Beachy +6 more
TL;DR: Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
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Sonic Hedgehog Mediates the Polarizing Activity of the ZPA
TL;DR: A vertebrate gene related to the Drosophila segment polarity gene hedgehog, which is expressed specifically in the ZPA and in other regions of the embryo, that is capable of polarizing limbs in grafting experiments is isolated.
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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Yann Echelard,Douglas J. Epstein,Benoit St-Jacques,Liya Shen,Jym Mohler,Jill A. McMahon,Andrew P. McMahon +6 more
TL;DR: Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
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Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
TL;DR: The mouse Hedgehog gene family consists of three members, Sonic, Desert, and Indian hedgehog (Shh, Dhh, and Ihh, respectively), relatives of the Drosophila segment polarity gene, hedgehog as mentioned in this paper.