Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Book ChapterDOI
Chapter 5 – A BRIEF HISTORICAL SURVEY OF CONCEPTS IN PAIN RESEARCH*
Lawrence Kruger,Sandra A. Kroin +1 more
Journal ArticleDOI
The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons
TL;DR: A potential mechanism by which cannabinoids produce hypothermia is demonstrated, and the effect of cannabinoids on thermoreceptive specific neurons in the spinal or medullary dorsal horn is suggested to affect non-noxious thermal discrimination.
Journal ArticleDOI
Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord.
TL;DR: The results showed that carbachol induces antiallodynic and anti-thermal hyperalgesic effects in a dose-dependent manner and there appears to be a neural pathway from the LH to the spinal cord, which potentially contributes to the modulation of neuropathic pain.
DissertationDOI
Modulation of (gamma)-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by (mu)-opioid receptor agonists and Ca²+/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission
TL;DR: Retrospective Theses and Dissertations 1995 Modulation of [gamma]-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by [mu]-opioid receptor agonists and Ca²+/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission
Journal ArticleDOI
Recovery of cutaneous vasomotor activity in the spinal dog.
TL;DR: Whereas thermal regulation by appropriate vasomotor response to peripheral cooling and warming is influenced by supraspinal systems, the vasom motor response recovers and functions appropriately after spinal shock has subsided, which suggests that vasomot regulation of body temperature is a primitive thermoregulatory response.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
Related Papers (5)
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more