Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Preferential immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in the sacral spinal cord of the cat: Light and electron microscopic observations
TL;DR: The spinal distribution of VIP-containing neuronal processes was compared with that of substance P, somatostatin, and cholecystokinin-8 at lumbar, sacral, and coccygeal levels and VIP, however, appears to be preferentially contained within pelvic visceral afferent fibers confined mostly to sacral segments.
Journal ArticleDOI
Morphology and synaptic connections of ultrafine primary axons in lamina I of the spinal dorsal horn: candidates for the terminal axonal arbors of primary neurons with unmyelinated (C) axons.
TL;DR: The morphology and synaptic connections of primary axons which generate axonal endings in lamina I of the spinal dorsal horn are examined and are thought to transfer nociceptive and thermal inputs directly to the dendritic arbors of lamina II neurons.
Book ChapterDOI
Chapter 13 An ascending general homeostatic afferent pathway originating in lamina I
TL;DR: This chapter discusses the major second-order central projection system that appears to have a fundamental role as a general homeostatic afferent system, and shows that projections from lamina I of the dorsal horn distribute activity originating from small-diameter input to several neural levels.
Journal ArticleDOI
Facilitation of the responses of primate spinothalamic cells to cold and to tactile stimuli by noxious heating of the skin
TL;DR: Damage to a region of skin can result in enhanced responsiveness of spinothalamic cells to stimuli applied in an undamaged region of the receptive field, provided the noxious heat was applied for a long enough time.
Journal ArticleDOI
Neurons at the origin of the medial component of the bulbopontine spinoreticular tract in the rat: an anatomical study using horseradish peroxidase retrograde transport.
TL;DR: An anatomical technique based on the retrograde transport of horseradish perodidase was used to investigate the progections of sponal cord neurions to the reticular formations in the rat.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more