Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Book ChapterDOI
Actions of opiate agonists and substance P on dorsal horn neurons of the cat
W. Zieglgänsberger,I. F. Tulloch +1 more
TL;DR: Investigations have shown that dorsal horn neurons are located in a region containing a high density of opiate binding sites and may have a central role in both morphine and stimulation-produced analgesia.
Book ChapterDOI
Projections of the Superficial Dorsal Horn to the Midbrain and Thalamus
TL;DR: Two of the somatosensory tracts from the spinal cord synapse on neurons in the midbrain and thalamus, and so can be designated spinomesencephalic and spinothalamic tracts.
Journal ArticleDOI
Passing lanes and slow lanes into the nociceptive network of the human brain.
TL;DR: Findings from EEG and MEG studies suggest a high degree of parallel rather than sequential processing in nociceptive brain areas.
Journal ArticleDOI
Characterization and pharmacological modulation of noci-responsive deep dorsal horn neurons across diverse rat models of pathological pain
TL;DR: Data from multiple individual experiments were combined to show firing properties of wide dynamic range and nociceptive specific spinal dorsal horn neurons across varied pathological pain models and the sensitization following different forms of injury is described.
Book ChapterDOI
The Superficial Dorsal Horn
TL;DR: The superficial dorsal horn is a morphologically distinct region of the grey matter of the spinal cord that has been recognized as a separate anatomical entity for over 150 years and points to fundamental differences in the processing of the sensory information mediated by fine afferent fibres as opposed to theprocessing of the signals carried by large myelinated afferents.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more