Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Light and electron microscopic evidence for a direct corticospinal projection to superficial laminae of the dorsal horn in cats and monkeys.
TL;DR: The anterograde transport of horseradish peroxidase (HRP) and wheat germ agglutin conjugated to horser Somalia peroxIDase (WGA‐ HRP) was employed in cats and monkeys to investigate the contribution of the corticospinal tract (CST) to the superficial laminae of the dorsal horn.
Journal ArticleDOI
Estrogenic influences in pain processing
Åsa Amandusson,Anders Blomqvist +1 more
TL;DR: The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.
Journal ArticleDOI
A system of rat spinal cord lamina 1 cells projecting through the contralateral dorsolateral funiculus.
TL;DR: The aim of these experiments was to sample the properties of lamina I neurones with long ascending projections and, in contrast to cells of deeper laminae, the majority of units were excited following activation of descending pathways in the dorsolateral funiculus.
Journal ArticleDOI
Morphology and Distribution of Spinothalamic Lamina I Neurons in the Monkey
En-Tan Zhang,A. D. Craig +1 more
TL;DR: It is concluded that three distinct morphological types of lamina I STT cells are present in the monkey as in the cat, and the present results support the possibility that these three cell types may correspond to distinct physiological classes of nociceptive and thermoreceptive lamina
Journal ArticleDOI
Vasoactive intestinal polypeptide and substance P in primary afferent pathways to the sacral spinal cord of the cat
TL;DR: An analysis of vasoactive intestinal polypeptide immunoreactivity (VIP‐IR) and substance P‐IR in the cat spinal cord has revealed marked differences in the distribution of the two peptides.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more