Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Different forms of glycine- and GABAA-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons
Wayne B. Anderson,Brett A. Graham,Natalie J. Beveridge,Paul A. Tooney,Alan M. Brichta,Robert J. Callister +5 more
TL;DR: Together these data show that Gly- and GABAARs with clearly differing physiological properties and cannabinoid-sensitivity contribute to fast synaptic inhibition in mouse SDH and DDH.
Journal ArticleDOI
Source imaging of the cortical 10 Hz oscillations during cooling and warming in humans.
TL;DR: Analysis of cortical activation during dynamic cooling and warming revealed cooling-sensitive activation in the bilateral posterior insula, PMC and the anterior cingulate cortex, which may aid in the anticipation of the cold temperature end-point and provide continuous evaluation of the thermal stimulus.
Journal ArticleDOI
Direct Comparison of Heat-Evoked Activity of Nociceptive Neurons in the Dorsal Horn With the Hindpaw Withdrawal Reflex in the Rat
TL;DR: Current classification schemes, in particular MR and NS categories, cannot be used as the sole criterion to predict involvement in nociceptive reflexes, however, simultaneous measurement of neural and reflex activity provides an opportunity to determine the characteristics of nOCiceptive neurons involved in withdrawal reflexes.
Journal ArticleDOI
Distribution of sensory neurons of the pudendal nerve in the dorsal root ganglia and their projection to the spinal cord. Horseradish-peroxidase studies in the rat.
TL;DR: The morphology and distribution of the sensory neurones of the pudendal nerve within the spinal ganglia of rats were investigated by use of horseradish peroxidase (HRP) and it is suggested that, in the rat, most of the small-diameter fibres within the pUDENDal nerve ascend through L6.
Journal ArticleDOI
Is neuropathic pain caused by the activation of nociceptive-specific neurons due to anatomic sprouting in the dorsal horn?
TL;DR: Allodynia, or abnormal responsiveness to somatic sensory stimulation, is a characteristic of neuropathic pain and innocuous stimuli excite neurons in the superficial dorsal horn and the parabrachial nucleus that are normally activated by noxious nociceptive pain.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more