Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Organization of trigeminothalamic tracts and other thalamic afferent systems of the brainstem in the rat: Presence of gelatinosa neurons with thalamic connections†
TL;DR: Thalamic projections from trigeminal and certain other nuclei of the brainstem of the rat have been investigated using the technique of retrograde transport of horseradish peroxidase (HRP).
Journal ArticleDOI
Projection Neurons in Lamina I of Rat Spinal Cord with the Neurokinin 1 Receptor Are Selectively Innervated by Substance P-Containing Afferents and Respond to Noxious Stimulation
TL;DR: It is concluded that presence or absence of the NK1 receptor is a better indicator of function than morphology for lamina I projection neurons in the rat, and for both substance P innervation and c-Fos expression there were no significant differences among different morphological types of NK1 receptors.
Journal ArticleDOI
Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn.
SP Schneider,Edward R. Perl +1 more
TL;DR: It is concluded that a subset of spinal neurons directly excited by dorsal root fibers have excitatory membrane receptors activated by L- glutamate, consistent with the concept that L-glutamate or a substance binding to the receptors it activates is released from the central terminals of some primary afferent fibers and mediates fast synaptic transmission from them to certain spinal neurons in the dorsal horn.
Journal ArticleDOI
Spinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus.
TL;DR: A major lamina I projection through the dorsolateral funiculi to the parabrachial area with significant collateralization to the thalamus in the rat is demonstrated and the understanding of spinal nociceptive mechanisms is concerns.
Book
Control of Nociceptive Transmission in the Spinal Cord
TL;DR: Soldering method comprises placing a cadmium-zinc-lead solder on a copper base and exposing the solder joint to about 200 DEG C. for at least one hour to produce a copper-cadmium -zinc ternary interface barrier layer which inhibits migration.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
Related Papers (5)
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more