Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers.
Alan R. Light,Edward R. Perl +1 more
TL;DR: Primary afferent fibers in the lumbar, sacral, and caudal spinal segments of several mammals (rat, cat, monkey) were stained by applying horseradish peroxidase to the proximal part of cut dorsal rootlets and reacting the tissue histochemically after several hours of survival.
Journal ArticleDOI
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief.
Eva Kosek,Gunnar Ordeberg +1 more
TL;DR: No pressure pain modulation was induced by HNCS in patients before surgery, as opposed to controls, suggesting a dysfunction in systems subserving ‘diffuse noxious inhibitory controls’ (DNIC).
Journal ArticleDOI
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Bo Duan,Longzhen Cheng,Longzhen Cheng,Steeve Bourane,Olivier Britz,Christopher Padilla,Lidia Garcia-Campmany,Michael J. Krashes,Wendy M. Knowlton,Tomoko Velasquez,Xiangyu Ren,Sarah E. Ross,Bradford B. Lowell,Yun Wang,Martyn Goulding,Qiufu Ma +15 more
TL;DR: In this article, intersectional genetic manipulations were used to identify the critical components of pain transduction in the spinal cord, including spinal SOM(+) excitatory and inhibitory neurons, coupled with behavioral and electrophysiological analysis.
Journal ArticleDOI
Neurons that subserve the sensory-discriminative aspects of pain.
Donald D. Price,Ronald Dubner +1 more
Book ChapterDOI
The Anatomy of Brain Stem Pathways to the Spinal Cord in Cat. A Labeled Amino Acid Tracing Study
TL;DR: The brain stem distribution of the cells of origin of these pathways in the cat has been reinvestigated by means of the horseradish peroxidase (HRP) technique by using the procedure of Mesulam to facilitate the identification of the various descending pathways.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
Related Papers (5)
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more