Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Cutaneous temperature receptors
TL;DR: Specific thermoreceptors comprise an electrophysiologically distinct class of cutaneous receptors with a morphological substrate (free nerve endings) and plausible transduction mechanism (electrogenic Na pump with or without auxiliary temperature-dependent processes) that have difficulty explaining the purity of cold and warm sensations.
Journal ArticleDOI
Ascending projections from marginal zone (Lamina I) neurons of the spinal dorsal horn
T. Kumazawa,T. Kumazawa,Edward R. Perl,Edward R. Perl,Paul R. Burgess,Paul R. Burgess,D. Whitehorn,D. Whitehorn +7 more
TL;DR: It is concluded that some Lamina I neurons form part of an ascending projection which follows the spinal pathway of the spinothalamic tract and thereby contribute to the mechanical nociceptive and thermoreceptive features of this pathway.
Journal ArticleDOI
Evidence of a specific spinal pathway for the sense of warmth in humans.
Gian Domenico Iannetti,Andrea Truini,A. Romaniello,F. Galeotti,C. Rizzo,M. Manfredi,Giorgio Cruccu +6 more
TL;DR: The results support the existence of slow-conducting second-order neurons specific for the sense of warmth in the central nervous system, and study the cortical areas involved in the cerebral processing of warm and nociceptive inputs.
Journal ArticleDOI
The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery.
TL;DR: In this paper, the effects of the gamma-aminobutyric acid (GABA) antagonist bicuculline (BCC) on hindlimb motor performance was examined in mature spinal cats with spinal cord transections made either on the day of birth or at approximately two weeks postpartum and in chronic adults with spinal transection made in adulthood.
Journal ArticleDOI
Psychological and Physiological Mechanisms of Pain
John C. Liebeskind,Linda A. Paul +1 more
TL;DR: The past decade has witnessed a remarkable expansion of interest in the scientific study of pain, driven by an outpouring of empirical filldings from a wide variety of experimental and clinical disciplines.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more