Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
The Ultrastructure and Synaptic Connections of Serotonin-Immunoreactive Terminals in Spinal Laminae I and II
TL;DR: The results suggest that there are heterogeneous serotonergic systems that may selectively modify different inputs postsynaptically to functionally different types of neurons in the superficial dorsal horn of the spinal cord.
Journal ArticleDOI
Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesia.
TL;DR: It is concluded that the NRA may act as a functional unit in the mediation of systemic morphine analgesia in contrast, analgesia elicited from intracerebral (PAG) morphine microinjection is mediated via the NRM.
Journal ArticleDOI
Distribution of primary afferent fibers within the sacrococcygeal dorsal horn: an autoradiographic study.
TL;DR: The spinal segmental distribution and intersegmental course of primary afferent fibers were studied by injecting tritiated amino acids into spinal ganglia of coccygeal and sacral segments and autoradiographically analyzing histological sections of the spinal cord, particularly those regions lying dorsal to the central canal.
Journal ArticleDOI
Temperature sensing across species
TL;DR: This review focuses on the three robust model systems extensively used to study sensory signaling, the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the laboratory mouse, focusing on the neuronal and molecular substrates for thermosensation.
Journal ArticleDOI
Is pain a specific sensation
TL;DR: This chapter discusses the analysis of pain as a specific sensation, and sets down attributes that might be accepted for this category in the light of Aristotle's view in setting pain opposite to pleasure and assigning it to the realm of emotion.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more