Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn
TL;DR: The responses of postsynaptic units to graded electrical volleys in intact dorsal roots and to physiological stimulation revealed that the peripheral excitatory input to neurons of the region is dominated by slowly conducting afferent fibers.
Journal ArticleDOI
Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.
Mirjana Randić,Vjekoslav Miletić +1 more
Journal ArticleDOI
Sensory dysfunction in fibromyalgia patients with implications for pathogenic mechanisms
Eva Kosek,Jan Ekholm,Per Hansson +2 more
TL;DR: The generalized increase in sensitivity found in FM patients was unrelated to spontaneous pain and thus most likely due to a central nervous system (CNS) dysfunction.
Journal ArticleDOI
Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control
TL;DR: The dorsal horn circuits that underlie the transmission of "pain" and "itch" messages are examined and the extent to which labeled lines can be incorporated into a contemporary view of GCT is addressed.
Journal ArticleDOI
Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis)
TL;DR: The translucent band which lies just beneath the spinal V tract at the lower end of the spinal trigeminal nucleus (nucleus caudalis) can be divided into three layers, distinguished by textural differences in their neuropil and by the morphology and laminar distribution of the axons and dendrites of their neurons.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more