Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Extracellular and intracellular recordings from neurones in the substantia gelatinosa Rolandi.
Journal ArticleDOI
Spinal cord projection neurons: a superficial, and also deep analysis
TL;DR: A major question addressed is the extent to which labeled-lines are maintained in these different populations or whether the brain generates distinct pain and itch percepts by decoding complex convergent inputs that engage projection neurons.
Journal ArticleDOI
Dorsolateral pontospinal systems. Possible routes for catecholamine modulation of nociception.
Journal ArticleDOI
Habenular neuron responses to noxious input are modified by dorsal raphe stimulation.
Nachum Dafny,J. T. Qiao +1 more
TL;DR: It was demonstrated that the habenular complex responds to noxious input and, together with other findings reporting that both direct morphine application into the Hab and electrical stimulation of the Hab produced analgesia, suggest that theHab is integrated into the pain regulatory circuitry.
Journal ArticleDOI
Response properties of nociceptive and low‐threshold neurons in rat trigeminal pars caudalis
TL;DR: The fundamental similarities in nociceptive properties in pars caudalis and other structures of the central nervous system suggest that there is little transformation of the information encoded at successive levels of the neuraxis, consistent with the idea that the functional role of nocICEptive neurons is refiected more in which circuits they are integrated and less in differences in their physiological properties.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more