Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
More filters
Journal ArticleDOI
The development of monoaminergic brainstem-spinal systems in the North American opossum.
TL;DR: In this article, the authors present evidence for an early appearance of monoaminergic neurites within the spinal cord of the developing opossum, showing that they are present within the marginal zone before hindlimb movements begin (stage I) and they start to grow into the intermediate zone by the time hind limb movements are first observed (stage II).
Journal ArticleDOI
Ventrolateral and dorsolateral ascending spinal cord pathway influence on thalamic nociception in cat
TL;DR: Thalamic neuronal responses to cutaneous noxious thermal stimuli are evaluated and the functional importance of pathways ascending in the ventral and dorsolateral portions of the spinal cord, ipsilateral to the thalamic recording site and contralateral to the hindlimb stimulation region, for transmission of nociceptive information to theThalamus is determined.
Journal ArticleDOI
A role for spinal lamina I neurokinin-1-positive neurons in cold thermoreception in the rat.
C.A. Doyle,S.P. Hunt +1 more
TL;DR: Data show that lamina I neurokinin-1 cells encode the intensity of noxious cooling of the skin in anaesthetized rats, and neurons in laminae III and IV may also play a role in thermoreception.
References
More filters
Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
Related Papers (5)
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more