Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Responses of rat dorsal horn neurons to natural stimulation and to iontophoretically applied norepinephrine
TL;DR: Both the inhibitory and excitatory effects of norepinephrine were stereoselective, but they were not blocked by receptor subtype‐selective antagonists.
Journal ArticleDOI
Ascending projections of nociceptor-driven Lamina I neurones in the cat
TL;DR: It is concluded that at least two-thirds of the population of nociceptor-driven Lamina I neurones are segmental interneurones.
Journal ArticleDOI
Thermoreceptive lamina I trigeminothalamic neurons project to the nucleus submedius in the cat
TL;DR: This finding indicates that Sm receives thermoreceptive in addition to nociceptive information in the medial thalamus of the cat.
Journal ArticleDOI
Is there a specific lamina I spinothalamocortical pathway for pain and temperature sensations in primates
TL;DR: The evidence indicates a view of ascending pain pathways that is conceptually distinct from Willis et al's view, as well as addressing a few major issues raised in their article.
Journal ArticleDOI
Substance P innervation of the rat and cat thalamus. II. Cells of origin in the spinal cord
Giorgio Battaglia,Aldo Rustioni +1 more
TL;DR: Evidence in the preceding paper suggests that fibers and terminals immunopositive for substance P (SP) in somatosensory thalamic nuclei are part of the spinothalamic tract (STT), and more direct evidence is provided by immunocytochemistry for SP on the cervical spinal cord.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more