Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Journal ArticleDOI
Placing pain on the sensory map: classic papers by Ed Perl and colleagues.
TL;DR: This essay looks at two papers published by Ed Perl and co-workers that identified specifically nociceptive neurons in the periphery and superficial dorsal horn that were specifically excited by noxious or thermal stimuli.
Dissertation
Descending control in sensitization of reflexes in the rat
TL;DR: Reflexes in animals with an intact spinal cord were facilitated or inhibited by MO application to ipsilateral hindlimb sites in a way that resembled the modular organization of reflexes per se and previous sensitization studies in the rabbit, suggesting that 5-HT3 receptors are indeed implicated in tonic descending facilitation of spinal reflexes.
Book ChapterDOI
Spinal Cord Cyto- and Chemoarchitecture
TL;DR: A large variety of neurochemical substances are found in neurons of Rexed’s laminae and spinal cord nuclei including acetylcholine, calbindin, calcitonin gene-related peptide, glutamate, nitric oxide and substance P.
Dissertation
Characterisation of interneurons in lamina II of the rat spinal cord
TL;DR: The results suggest that excitatory lamina II interneurons with IA –type firing patterns are involved in plasticity that contributes to pain states, and suggests that the pro-nociceptive effects of somatostatin are mediated by ‘disinhibition’.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
Related Papers (5)
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more