Journal ArticleDOI
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
B N Christensen,Edward R. Perl +1 more
TLDR
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin.Abstract:
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17). The argument for their relation to pain was based on two points: 1) the ability of such afferent elements, unique among those with medullated fibers, to provide signals differentiating noxious from innocuous mechanical events affecting the skin; and 2) the well-established correlation between pain and activity in thin myelinated afferent fibersread more
Citations
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Peptides as neuromodulators in primary sensory neurons
TL;DR: The neurokinins, in particular substance P, can be taken as prototypes of modulating peptides in primary sensory neurons and act synaptically and non-synaptically in autonomic ganglia and other peripheral targets.
Journal ArticleDOI
Effects of systemic morphine on lamina I spinothalamic tract neurons in the cat
A.D. (Bud) Craig,L.P. Serrano +1 more
TL;DR: The effects of successive, cumulative doses of intravenous morphine sulfate on the quantitative stimulus-response properties of nociceptive lamina I STT cells have been tested in the intact, barbiturate-anesthetized cat and these results support previous evidence that opiatergic modulation of sensory activity in lamina II is functionally organized.
Journal ArticleDOI
Spinal cord coding of graded nonnoxious and noxious temperature increases.
TL;DR: The response of the population of noxious heat units was linearly related to skin temperature from 43 to 49 C, similar to the psychophysical curve of pain intensity over the same temperature range, and recruitment of higher threshold units may be an important factor in coding nociceptive information.
Journal ArticleDOI
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones
TL;DR: The aim of this study was to compare TRPM8 and TRPA1 modulation of glutamatergic afferent transmission within the spinal dorsal horn.
Journal ArticleDOI
Somatic responses of ventrobasal thalamic neurones in polyarthritic rats
Michèle Gautron,Gisèle Guilbaud +1 more
TL;DR: In this paper, the unitary responses of ventrobasal thalamic neurons to somatic stimulations were dramatically modified by comparison to those described in normal rats investigated in the same anaesthetic conditions.
References
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Journal ArticleDOI
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more
TL;DR: In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.
Journal ArticleDOI
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Paul R. Burgess,Edward R. Perl +1 more
TL;DR: The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes with distinctive features of 513 fibres conducting under 51 m/sec.
Journal ArticleDOI
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli.
TL;DR: The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes or from fine filaments prepared by dissection.
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Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
P Bessou,Edward R. Perl +1 more