Structural mechanism of ring-opening reaction of glucose by human serum albumin
TLDR
Two protein crystal structures of HSA in complex with either glucose or fructose reveal the presence of linear forms of sugar for both monosaccharides and propose a mechanism for glucose ring opening involving both residues Lys-195 and Lys-199.About:
This article is published in Journal of Biological Chemistry.The article was published on 2013-05-31 and is currently open access. It has received 104 citations till now. The article focuses on the topics: Glycation & Human serum albumin.read more
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Interactive Association of Drugs Binding to Human Serum Albumin
Feng Yang,Yao Zhang,Hong Liang +2 more
TL;DR: This review will succinctly outline the properties of binding site of drugs in IIA subdomain within the structure of HSA to give an overview on the binding characterization of interactive association of drugs to human serum albumin that may potentially lead to significant clinical applications.
Journal ArticleDOI
Structure, enzymatic activities, glycation and therapeutic potential of human serum albumin: A natural cargo
Gulam Rabbani,Sae-Young Ahn +1 more
TL;DR: Human serum albumin is one of the most suitable molecules for future research in drug discovery in pharmaceutical industry because of its numerous features and binding pattern that also governs the metabolism and drug dosage.
Journal ArticleDOI
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery
Malin C. Bern,Kine Marita Knudsen Sand,Kine Marita Knudsen Sand,Jeannette Nilsen,Inger Sandlie,Inger Sandlie,Jan Terje Andersen +6 more
TL;DR: The current understanding of albumin homeostasis is reviewed with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin-megalin complex, and their importance on uses ofalbumin in drug delivery is discussed.
Journal ArticleDOI
Paper‐Based Ratiometric Fluorescence Analytical Devices towards Point‐of‐Care Testing of Human Serum Albumin
Zijie Luo,Zijie Luo,Taoyuze Lv,Kangning Zhu,Yi Li,Lei Wang,J. Justin Gooding,Guozhen Liu,Bin Liu +8 more
TL;DR: A dual-state emissive chalcone probe having the feature of aggregation-induced emission is designed and synthesized, providing a promising tool for at-home HSA detection and HSA-related disease diagnosis.
Journal ArticleDOI
Capping gold nanoparticles with albumin to improve their biomedical properties.
TL;DR: The features of albumin are reviewed, as well as its interaction with AuNPs, focusing on its biomedical applications, which have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation.
References
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TL;DR: An overview of the CCP4 software suite for macromolecular crystallography is given.