Journal ArticleDOI
Structure and design of polymeric surfactant-based drug delivery systems.
TLDR
The review concentrates on the use of polymeric micelles as pharmaceutical carriers and the basic mechanisms underlying micelle longevity and steric protection in vivo are considered with a special emphasis on long circulating drug delivery systems.About:
This article is published in Journal of Controlled Release.The article was published on 2001-06-15. It has received 1670 citations till now. The article focuses on the topics: Critical micelle concentration & Micelle.read more
Citations
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PatentDOI
Self-assembly and mineralization of peptide-amphiphile nanofibers
TL;DR: In this paper, pH-induced self-assembly of a peptide-amphiphile was used to make a nanostructured fibrous scaffold reminiscent of extracellular matrix.
Journal ArticleDOI
Micellization of block copolymers
TL;DR: A general overview of the preparation, characterization and theories of block copolymer micellar systems is presented in this paper, with examples of micelle formation in aqueous and organic medium are given for di-and triblock copolymers, as well as for more complex architectures.
Journal ArticleDOI
Tumor delivery of macromolecular drugs based on the EPR effect
TL;DR: The role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPReffect-mediated accumulation of drug-containing macromolescular systems in tumors.
Journal ArticleDOI
Micellar nanocarriers: pharmaceutical perspectives.
TL;DR: This review will discuss some recent trends in using micelles as pharmaceutical carriers, including lipid-core micells, which may become the imaging agents of choice in different imaging modalities.
Journal ArticleDOI
Block copolymer micelles: preparation, characterization and application in drug delivery.
Geneviève Gaucher,Marie-Hélène Dufresne,Vinayak Sant,Ning Kang,Dusica Maysinger,Jean-Christophe Leroux +5 more
TL;DR: The innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research are proposed.
References
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Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
Book
Foundations of Colloid Science
TL;DR: The structure of concentrated dispersions thin films Emulsions Microemulsions Rheology of colloidal dispersions and their properties are described in detail in this paper, with a focus on statistical mechanics of fluids.
Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Susan K. Hobbs,Wayne L. Monsky,Fan Yuan,W. G. Roberts,Linda G. Griffith,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.
Journal ArticleDOI
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers.
Lifeng Zhang,Adi Eisenberg +1 more
TL;DR: A needle-like solid is obtained on drying of aqueous solutions of the spherical micelles of the highly asymmetric polystyrene-poly-(acrylic acid) block copolymers prepared in a low molecular weight solvent system.