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Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis

Brijesh S. Kadu
- 02 Mar 2021 - 
- Vol. 11, Iss: 4, pp 1186-1221
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TLDR
The advancements (within the last 4 years) in catalysis related to SMCR that would be beneficial for researchers in designing synthetic protocols for the preparation of pharmacophores as well as drug molecules are discussed.
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This article is published in Catalysis Science & Technology.The article was published on 2021-03-02. It has received 68 citations till now. The article focuses on the topics: Organic synthesis.

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Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling

TL;DR: A nickel-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity and unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions.
Journal ArticleDOI

Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

TL;DR: In this paper , the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding, namely, organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
Journal ArticleDOI

The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery

TL;DR: In this paper, the authors discuss the recent trends of C-H activation methodologies such as synthesis of medicinal scaffolds through a cascade of cascade-based activation and activation/annulation cascade, arylation for sp2sp2 and sp2-sp3 cross-coupling, borylation/silylation to introduce a functional linchpin for further manipulation, amination for N-heterocycles and hydrogen bond acceptors, C-h fluorination/fluoroalkylation to tune polarity and lipophilicity, peptide modification and
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Stabilization of ruthenium on biochar-nickel magnetic nanoparticles as a heterogeneous, practical, selective, and reusable nanocatalyst for the Suzuki C–C coupling reaction in water

Parisa Moradi, +1 more
- 28 Apr 2022 - 
TL;DR: In this article , Ru-dithizone@biochar-Ni MNPs were modified by dithizones ligand and then applied for the fabrication of a ruthenium catalyst.

Nickel-Catalyzed Carbon–Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations

TL;DR: This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction.
References
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Journal ArticleDOI

Transition-metal-catalyzed Suzuki-Miyaura cross-coupling reactions: a remarkable advance from palladium to nickel catalysts

TL;DR: A broad range of aryl electrophiles, which are conventionally challenging, by applying palladium catalysts can now be coupled efficiently with boron reagents in the presence of nickel catalysts.
Journal ArticleDOI

Organic synthesis provides opportunities to transform drug discovery

TL;DR: This Perspective highlights some of the most pressing challenges to be overcome from the industrial viewpoint — such as the development of reactions tolerating specific functionalities — and encourages stronger industry–academia relationships.
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High-valent organometallic copper and palladium in catalysis

TL;DR: Recent advances involving both the fundamental chemistry and the applications of these high-valent metal complexes in numerous synthetically useful catalytic transformations are described.
Journal ArticleDOI

Cobalt-Catalyzed Cross-Coupling Reactions

TL;DR: Alkenylation of Acetylenic Grignard Reagents 1447 6.1.3.
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Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

TL;DR: In this article, a review of the state of the art in the field of the synthesis and the application of silica-supported Pd catalysts in carbon-carbon and carbon-nitrogen coupling reactions is presented.
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