Journal ArticleDOI
Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis
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TLDR
The advancements (within the last 4 years) in catalysis related to SMCR that would be beneficial for researchers in designing synthetic protocols for the preparation of pharmacophores as well as drug molecules are discussed.About:
This article is published in Catalysis Science & Technology.The article was published on 2021-03-02. It has received 68 citations till now. The article focuses on the topics: Organic synthesis.read more
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Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling
TL;DR: A nickel-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity and unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions.
Journal ArticleDOI
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Federico Cuccu,Lidia De Luca,Francesco Delogu,Evelina Colacino,Niclas Solin,Rita Mocci,Andrea Porcheddu +6 more
TL;DR: In this paper , the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding, namely, organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
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The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
TL;DR: In this paper, the authors discuss the recent trends of C-H activation methodologies such as synthesis of medicinal scaffolds through a cascade of cascade-based activation and activation/annulation cascade, arylation for sp2sp2 and sp2-sp3 cross-coupling, borylation/silylation to introduce a functional linchpin for further manipulation, amination for N-heterocycles and hydrogen bond acceptors, C-h fluorination/fluoroalkylation to tune polarity and lipophilicity, peptide modification and
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Stabilization of ruthenium on biochar-nickel magnetic nanoparticles as a heterogeneous, practical, selective, and reusable nanocatalyst for the Suzuki C–C coupling reaction in water
Parisa Moradi,Maryam Hajjami +1 more
TL;DR: In this article , Ru-dithizone@biochar-Ni MNPs were modified by dithizones ligand and then applied for the fabrication of a ruthenium catalyst.
Nickel-Catalyzed Carbon–Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
TL;DR: This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction.
References
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Ruthenium-catalyzed Suzuki coupling of anilines with alkenyl borates via selective aryl CN bond cleavage
TL;DR: In this article, a ruthenium(0)-catalyzed Suzuki-coupling of N,N-dimethyl-2-(pyridin-2-yl) anilines with alkenyl borates was developed to synthesize 2-phenylolefins via the cleavage of neutral aryl C N bond.
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Mechanism and Origin of Enantioselectivity in Nickel-Catalyzed Alkyl-Alkyl Suzuki Coupling Reaction.
Sukriti Singh,Raghavan B. Sunoj +1 more
TL;DR: The most preferred catalytic pathway is found to proceed through a Ni(I)/Ni( III) redox cycle with key mechanistic steps such as a transmetalation involving the transfer of the alkyl group of 9-BBN to the Ni-catalyst, an oxidative addition of bromo(fluoro) alkane to give a penta-coordinate Ni(III) intermediate, and an enantio-controlling reductive elimination that facilitates the C-C
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Fe–Ni/MMT nanocomposites as efficient H2 generation catalyst: Tandem approach towards one-pot synthesis of secondary amines
TL;DR: In this paper, a non-noble metal-based bifunctional Fe-Ni/MMT nanocomposites exhibit excellent H2 generation capability from the methanolysis of NaBH4 at a rate of 16,200mLmin−1,g−1Fe-Ni with 10%Fe−Ni loading on MMT support.
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Synthesis of brominated bisamides and their application to the suzuki coupling
TL;DR: In this article, two brominated bisamides were developed by using 4-bromobenzoyl chloride and ethylenediamine or by ortho-phenylensiamine.
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Suzuki cross coupling followed by cross dehydrogenative coupling: An efficient one pot synthesis of Phenanthrenequinones and analogues
TL;DR: In this article, an efficient one pot protocol was developed for the synthesis of substituted phenanthrenequinone and analogous derivatives via Suzuki cross coupling followed by copper catalyzed cross dehydrogenative coupling.
Related Papers (5)
The B‐Alkyl Suzuki—Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis
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Palladium-Catalyzed Suzuki-Miyaura Cross-coupling Reactions Employing Dialkylbiaryl Phosphine Ligands
Ruben Martin,Stephen L. Buchwald +1 more