Journal ArticleDOI
Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis
TLDR
The advancements (within the last 4 years) in catalysis related to SMCR that would be beneficial for researchers in designing synthetic protocols for the preparation of pharmacophores as well as drug molecules are discussed.About:
This article is published in Catalysis Science & Technology.The article was published on 2021-03-02. It has received 68 citations till now. The article focuses on the topics: Organic synthesis.read more
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Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling
TL;DR: A nickel-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity and unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions.
Journal ArticleDOI
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Federico Cuccu,Lidia De Luca,Francesco Delogu,Evelina Colacino,Niclas Solin,Rita Mocci,Andrea Porcheddu +6 more
TL;DR: In this paper , the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding, namely, organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
Journal ArticleDOI
The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
TL;DR: In this paper, the authors discuss the recent trends of C-H activation methodologies such as synthesis of medicinal scaffolds through a cascade of cascade-based activation and activation/annulation cascade, arylation for sp2sp2 and sp2-sp3 cross-coupling, borylation/silylation to introduce a functional linchpin for further manipulation, amination for N-heterocycles and hydrogen bond acceptors, C-h fluorination/fluoroalkylation to tune polarity and lipophilicity, peptide modification and
Journal ArticleDOI
Stabilization of ruthenium on biochar-nickel magnetic nanoparticles as a heterogeneous, practical, selective, and reusable nanocatalyst for the Suzuki C–C coupling reaction in water
Parisa Moradi,Maryam Hajjami +1 more
TL;DR: In this article , Ru-dithizone@biochar-Ni MNPs were modified by dithizones ligand and then applied for the fabrication of a ruthenium catalyst.
Nickel-Catalyzed Carbon–Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
TL;DR: This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction.
References
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Journal ArticleDOI
The copper-catalysed Suzuki-Miyaura coupling of alkylboron reagents: disproportionation of anionic (alkyl)(alkoxy)borates to anionic dialkylborates prior to transmetalation.
TL;DR: Results from a radical clock experiment and the Hammett plot imply that the reaction likely proceeds via a non-radical pathway, and the first example of Cu(I)-catalysed coupling of alkylboron reagents with aryl and heteroaryl iodides that affords products in good to excellent yields is reported.
Journal ArticleDOI
The synergistic effect of cobalt on a Pd/Co catalyzed Suzuki–Miyaura cross-coupling in water
Li-Xin You,Hui-Jie Liu,Lan-Xin Cui,Fu Ding,Gang Xiong,Shu-Ju Wang,Bao-Yi Ren,Ileana Dragutan,Valerian Dragutan,Yaguang Sun +9 more
TL;DR: Catalytic studies revealed a synergistic Co-Pd cooperativity, fostered by ligation through H2BPDC, and accounting for the superior performance of the heterobimetallic complex vs. its Co-free counterpart.
Journal ArticleDOI
Synthesis, characterization and biological activities of 3-aryl-1,4-naphthoquinones – green palladium-catalysed Suzuki cross coupling
Aline da Rocha Louvis,Nayane Abreu do Amaral e Silva,Felipe S. Semaan,Fernando de C. da Silva,Gabriela Saramago,Lais C Dos S Velasco de Souza,Bruno Leal Alves Ferreira,Helena Carla Castro,Juliana Pimenta Salles,André Luis Almeida Souza,Robson Xavier Faria,Vitor F. Ferreira,Daniela de Luna Martins +12 more
TL;DR: The Osiris and Molinspiration Cheminformatics programs, utilizing in silico analyses, imply that these naphthoquinones are candidates for use as drugs which was reinforced by the outcomes of the in vitro antifungal and trypanocidal activity tests.
Journal ArticleDOI
Confirmation of Suzuki-Miyaura Cross-Coupling Reaction Mechanism through Synthetic Architecture of Nanocatalysts
Bo Sun,Lulu Ning,Hua Chun Zeng +2 more
TL;DR: It is found that the leached Pd species are the only genuine catalytic intermediate in the cross-coupling reactions and oxidative addition of aryl halides to the solid Pd leads to leaching of the soluble PD species which is necessary to promote Suzuki-Miyaura reactions.
Journal ArticleDOI
In situ generation of supported palladium nanoparticles from a Pd/Sn/S chalcogel and applications in 4-nitrophenol reduction and Suzuki coupling
TL;DR: In this article, a one-step in situ route to well-defined Pd nanoparticles through reduction of a Pd-containing chalcogel with tunable size distribution is presented.
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The B‐Alkyl Suzuki—Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis
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Palladium-Catalyzed Suzuki-Miyaura Cross-coupling Reactions Employing Dialkylbiaryl Phosphine Ligands
Ruben Martin,Stephen L. Buchwald +1 more