Journal ArticleDOI
Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis
TLDR
The advancements (within the last 4 years) in catalysis related to SMCR that would be beneficial for researchers in designing synthetic protocols for the preparation of pharmacophores as well as drug molecules are discussed.About:
This article is published in Catalysis Science & Technology.The article was published on 2021-03-02. It has received 68 citations till now. The article focuses on the topics: Organic synthesis.read more
Citations
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Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling
TL;DR: A nickel-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity and unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions.
Journal ArticleDOI
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Federico Cuccu,Lidia De Luca,Francesco Delogu,Evelina Colacino,Niclas Solin,Rita Mocci,Andrea Porcheddu +6 more
TL;DR: In this paper , the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding, namely, organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
Journal ArticleDOI
The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
TL;DR: In this paper, the authors discuss the recent trends of C-H activation methodologies such as synthesis of medicinal scaffolds through a cascade of cascade-based activation and activation/annulation cascade, arylation for sp2sp2 and sp2-sp3 cross-coupling, borylation/silylation to introduce a functional linchpin for further manipulation, amination for N-heterocycles and hydrogen bond acceptors, C-h fluorination/fluoroalkylation to tune polarity and lipophilicity, peptide modification and
Journal ArticleDOI
Stabilization of ruthenium on biochar-nickel magnetic nanoparticles as a heterogeneous, practical, selective, and reusable nanocatalyst for the Suzuki C–C coupling reaction in water
Parisa Moradi,Maryam Hajjami +1 more
TL;DR: In this article , Ru-dithizone@biochar-Ni MNPs were modified by dithizones ligand and then applied for the fabrication of a ruthenium catalyst.
Nickel-Catalyzed Carbon–Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
TL;DR: This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction.
References
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Immobilization of palladium nanoparticles on ionic liquid-triethylammonium chloride functionalized magnetic nanoparticles: As a magnetically separable, stable and recyclable catalyst for Suzuki-Miyaura cross-coupling reactions
TL;DR: A facile procedure was applied to successfully synthesize novel Pd nanoparticles immobilized on triethanolamine-functionalized magnetic nanoparticles [Fe 3 O 4 /IL/Pd] as mentioned in this paper.
Journal ArticleDOI
Reaction scope and mechanistic insights of nickel-catalyzed migratory Suzuki-Miyaura cross-coupling.
Yuqiang Li,Yixin Luo,Long Peng,Yangyang Li,Binzhi Zhao,Wang Wang,Hailiang Pang,Yi Deng,Ruopeng Bai,Yu Lan,Yu Lan,Guoyin Yin +11 more
TL;DR: In this paper, a Ni-catalyzed migratory Suzuki-Miyaura cross-coupling featuring high benzylic or allylic selectivity has been developed, which can serve as a platform for the synthesis of terminal, partially deuterium-labeled molecules from readily accessible starting materials.
Journal ArticleDOI
Acetamidine–palladium complex immobilized on γ-Fe2O3 nanoparticles: a novel magnetically separable catalyst for Heck and Suzuki coupling reactions
TL;DR: In this paper, a new palladium-Schiff base complex was synthesized via the reaction of amino-functionalized γ-Fe2O3 with acetamide followed by the reaction with palladium acetate.
Journal ArticleDOI
Nickel-Catalyzed Cross-Coupling of Chromene Acetals and Boronic Acids
TL;DR: A modular and highly efficient protocol for the synthesis of 2-aryl- and heteroaryl-2H-chromenes is described and has been applied to the late-stage incorporation of complex molecules, including the pharmaceuticals loratidine and indomethacin methyl ester.
Journal ArticleDOI
An air-stable binary Ni(0)–olefin catalyst
TL;DR: In this article, the synthesis, characterization and reactivity of an air stable binary Ni(0)-olefin complex, Ni(Fstb)3, has been presented, which is an excellent precatalyst in a wide variety of important nickel-catalysed transformations.
Related Papers (5)
The B‐Alkyl Suzuki—Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis
Oxygen-Promoted Suzuki-Miyaura Reaction for Efficient Construction of Biaryls
Palladium-Catalyzed Suzuki-Miyaura Cross-coupling Reactions Employing Dialkylbiaryl Phosphine Ligands
Ruben Martin,Stephen L. Buchwald +1 more