Journal ArticleDOI
Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis
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TLDR
The advancements (within the last 4 years) in catalysis related to SMCR that would be beneficial for researchers in designing synthetic protocols for the preparation of pharmacophores as well as drug molecules are discussed.About:
This article is published in Catalysis Science & Technology.The article was published on 2021-03-02. It has received 68 citations till now. The article focuses on the topics: Organic synthesis.read more
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Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling
TL;DR: A nickel-catalyzed migratory Suzuki–Miyaura cross-coupling featuring high benzylic or allylic selectivity and unactivated alkyl electrophiles and aryl or vinyl boronic acids can be efficiently transferred to diarylalkane or allylbenzene derivatives under mild conditions.
Journal ArticleDOI
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Federico Cuccu,Lidia De Luca,Francesco Delogu,Evelina Colacino,Niclas Solin,Rita Mocci,Andrea Porcheddu +6 more
TL;DR: In this paper , the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding, namely, organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
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The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
TL;DR: In this paper, the authors discuss the recent trends of C-H activation methodologies such as synthesis of medicinal scaffolds through a cascade of cascade-based activation and activation/annulation cascade, arylation for sp2sp2 and sp2-sp3 cross-coupling, borylation/silylation to introduce a functional linchpin for further manipulation, amination for N-heterocycles and hydrogen bond acceptors, C-h fluorination/fluoroalkylation to tune polarity and lipophilicity, peptide modification and
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Stabilization of ruthenium on biochar-nickel magnetic nanoparticles as a heterogeneous, practical, selective, and reusable nanocatalyst for the Suzuki C–C coupling reaction in water
Parisa Moradi,Maryam Hajjami +1 more
TL;DR: In this article , Ru-dithizone@biochar-Ni MNPs were modified by dithizones ligand and then applied for the fabrication of a ruthenium catalyst.
Nickel-Catalyzed Carbon–Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
TL;DR: This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction.
References
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Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates
TL;DR: A rhodium-catalysed asymmetric Suzuki-Miyaura reaction with important partners including aryls, vinyls, heteroaromatics and heterocycles is reported, used to synthesize isoanabasine, preclamol, and niraparib—an anticancer agent in several clinical trials.
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Stereospecific cross-coupling between alkenylboronates and alkyl halides catalyzed by iron-bisphosphine complexes.
TL;DR: Various nonactivated alkyl bromides and chlorides possessing a base/nucleophile-sensitive functional group can participate in the cross-coupling, demonstrating its utility for stereoselective synthesis of functional molecules bearing a carbon-carbon double bond.
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Efficiency and recycling capability of montmorillonite supported Fe–Ni bimetallic nanocomposites towards hexavalent chromium remediation
Brijesh S. Kadu,Yogesh D. Sathe,Abhijit B. Ingle,Rajeev C. Chikate,Kashinath R. Patil,Chandrashekhar V. Rode +5 more
TL;DR: In this paper, the remediation of Cr(VI) from simulated water streams is investigated using Fe-Ni bimetallic nanoparticles (Fe-Ni NPs) and their nanocomposites prepared with montmorillonite (MMT) clay.
Journal ArticleDOI
Maghemite decorated with ultra-small palladium nanoparticles (γ-Fe2O3–Pd): applications in the Heck–Mizoroki olefination, Suzuki reaction and allylic oxidation of alkenes
Anuj K. Rathi,Manoj B. Gawande,Jiri Pechousek,Jiri Tucek,Claudia Aparicio,Martin Petr,Ondrej Tomanec,Radka Krikavova,Zdenek Travnicek,Rajender S. Varma,Radek Zboril +10 more
TL;DR: In this paper, a nanocatalyst comprising ultra-small Pd/PdO nanoparticles supported on maghemite was prepared by a co-precipitation protocol using inexpensive raw materials and was deployed successfully in various significant synthetic transformations, namely the Heck-Mizoroki olefination (up to 95%), the Suzuki reaction (60-95%), and the allylic oxidation of alkenes under milder conditions.
Journal ArticleDOI
Nickel-Catalyzed Suzuki-Miyaura Coupling of Aliphatic Amides.
TL;DR: The Ni-catalyzed Suzuki-Miyaura coupling provides an efficient means to form C-C bonds from aliphatic amide derivatives using nonprecious-metal catalysis and offers a general platform for the heteroarylation ofAliphatic acyl electrophiles.
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The B‐Alkyl Suzuki—Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis
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Palladium-Catalyzed Suzuki-Miyaura Cross-coupling Reactions Employing Dialkylbiaryl Phosphine Ligands
Ruben Martin,Stephen L. Buchwald +1 more