Journal ArticleDOI
Synthesis of Unnatural α-Amino Acids via Photoinduced Decatungstate-Catalyzed Giese Reactions of Aldehydes
TLDR
In this paper, photo-induced decatungstate-catalyzed Giese reactions of readily available aldehydes as radical precursors are used to synthesize α-amino acids.About:
This article is published in Organic Letters.The article was published on 2021-03-04. It has received 33 citations till now. The article focuses on the topics: Amino acid.read more
Citations
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Journal ArticleDOI
Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C-H Bonds Elaboration
TL;DR: A comprehensive review of the synthetic applications of photocatalyzed d-HAT can be found in this article, where the authors provide a comprehensive overview of the main applications of PCHAT.
Journal ArticleDOI
Visible Light-Induced Transition Metal Catalysis.
TL;DR: In this paper, a transition metal complex serves a double duty by harvesting photon energy and then enabling bond forming/breaking events mostly via a single catalytic cycle, thus contrasting the established dual photocatalysis in which an exogenous photosensitizer is employed.
Journal ArticleDOI
Recent advances in acyl radical enabled reactions between aldehydes and alkenes
TL;DR: A summary of the state of the art in this field with a specific emphasis on the working models and corresponding mechanisms is provided in this paper, where the discussion is divided according to the kind of alkenes and reaction type.
Journal ArticleDOI
Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles.
Mengran Wang,Chao Wang,Yumei Huo,Xiaobo Dang,Xue Hongxiang,Liangyu Liu,Hongli Chai,Xiuling Xie,Zhixuan Li,Doudou Lu,Zhaoqing Xu,Zhaoqing Xu +11 more
TL;DR: In this paper, an ionic compound was proposed to promote homolytic cleavage of pyridinium C-N bond by exploiting the photonic energy from visible light, which was successfully applied in deaminative hydroalkylation of a series of alkenes including naturally occurring dehydroalanine.
Journal ArticleDOI
Synthesis of γ-Oxo-α-amino Acids via Radical Acylation with Carboxylic Acids.
TL;DR: In this paper, a light-mediated, deoxygenative protocol was proposed to access γ-oxo-α-amino acid derivatives, which employs photoredox catalysis, in combination with triphenylphosphine, to generate acyl radicals from readily available (hetero)aromatic and vinylic carboxylic acids.
References
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Journal ArticleDOI
Enantioselective amino acid synthesis by chiral phase-transfer catalysis.
Keiji Maruoka,Takashi Ooi +1 more
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Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
TL;DR: The results demonstrate the saturable transfer of L‐KYN across the blood–brain barrier and suggest that circulating L‐ KYN, 3‐HKYN, and ANA may each contribute significantly to respective cerebral pools under normal conditions.
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Catalytic Asymmetric Synthesis of α-Amino Acids
Carmen Nájera,José M. Sansano +1 more
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C-H functionalization in the synthesis of amino acids and peptides.
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Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization
TL;DR: P palladium-catalyzed bidentate auxiliary-directed C-H functionalization reactions for αAA substrates enable new retrosynthetic logic for the synthesis of many basic αAAs from a common alanine precursor and may facilitate the efficient total synthesis of complex peptide natural products.