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Synthetic Biology: Bits and pieces come to life
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This article is published in Nature.The article was published on 2012-02-29. It has received 44 citations till now. The article focuses on the topics: Synthetic biology.read more
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Synthetic biology and conservation of nature: wicked problems and wicked solutions.
TL;DR: Synthetic biology is likely to transform the operating space within which conservation functions, and therefore the prospects for maintaining biodiversity into the future.
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From flavors and pharmaceuticals to advanced biofuels: production of isoprenoids in Saccharomyces cerevisiae.
TL;DR: The development of isoprenoid applications from flavors and pharmaceuticals to advanced biofuels is summarized and the strategies to design microbial cell factories are reviewed, focusing on Saccharomyces cerevisiae for the production of these compounds.
Journal Article
When the Material Grows: A Case Study on Designing (with) Mycelium-Based Materials
TL;DR: In this paper, a product design master's student followed the material driven design (MDD) method through a six-month graduation project, in search of a product application idea for a material that is intentionally grown for design purposes, namely, mycelium-based materials.
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Fabricating materials from living organisms: An emerging design practice
Serena Camere,Elvin Karana +1 more
TL;DR: In this paper, the authors discuss the need for developing new sensibilities to face complex interdisciplinary problems in Growing Design and highlight the role designers can take in developing new materials for sustainable production.
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Metabolic engineering for isoprenoid-based biofuel production
TL;DR: The engineered isoprenoid biosynthetic pathways in well‐characterized microbial systems for the production of several isopranoid‐based biofuels and fuel precursors are described.
References
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Journal ArticleDOI
A synthetic oscillatory network of transcriptional regulators
TL;DR: This work used three transcriptional repressor systems that are not part of any natural biological clock to build an oscillating network, termed the repressilator, in Escherichia coli, which periodically induces the synthesis of green fluorescent protein as a readout of its state in individual cells.
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Construction of a genetic toggle switch in Escherichia coli
TL;DR: The construction of a genetic toggle switch is presented—a synthetic, bistable gene-regulatory network—in Escherichia coli and a simple theory is provided that predicts the conditions necessary for bistability.
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Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae-Kyun Ro,Eric M. Paradise,Mario Ouellet,Karl Fisher,Karyn L. Newman,John M. Ndungu,Ho Kimberly,Eachus Rachel,Timothy S. Ham,James Kirby,Michelle C. Y. Chang,Sydnor T. Withers,Yoichiro Shiba,Richmond Sarpong,Jay D. Keasling +14 more
TL;DR: The engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l-1) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase from A. annua that performs a three-step oxidation of amorpha-4,11-diene to art Artemisinic acid.
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Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Daniel G. Gibson,John I. Glass,Carole Lartigue,Vladimir N. Noskov,Ray-Yuan Chuang,Mikkel A. Algire,Gwynedd A. Benders,Michael G. Montague,Li Ma,Monzia Moodie,Chuck Merryman,Sanjay Vashee,Radha Krishnakumar,Nacyra Assad-Garcia,Cynthia Andrews-Pfannkoch,Evgeniya A. Denisova,Lei Young,Zhi-Qing Qi,Thomas H. Segall-Shapiro,Christopher H. Calvey,Prashanth P. Parmar,Clyde A. Hutchison,Hamilton O. Smith,J. Craig Venter +23 more
TL;DR: The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.
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Synthetic biology: applications come of age.
TL;DR: The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.