Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses
Vanesa Bellou,Lazaros Belbasis,Ioanna Tzoulaki,Ioanna Tzoulaki,Lefkos T. Middleton,John P. A. Ioannidis,Evangelos Evangelou,Evangelos Evangelou +7 more
TLDR
Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors.Abstract:
Introduction Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. Methods We searched PubMed to identify meta-analyses of observational studies that examined associations between nongenetic factors and dementia. We estimated the summary effect size using random-effects and fixed-effects model, the 95% CI, and the 95% prediction interval. We assessed the between-study heterogeneity (I-square), evidence of small-study effects, and excess significance. Results A total of 76 unique associations were examined. By applying standardized criteria, seven associations presented convincing evidence. These associations pertained to benzodiazepines use, depression at any age, late-life depression, and frequency of social contacts for all types of dementia; late-life depression for Alzheimer's disease; and type 2 diabetes mellitus for vascular dementia and Alzheimer's disease. Discussion Several risk factors present substantial evidence for association with dementia and should be assessed as potential targets for interventions, but these associations may not necessarily be causal.read more
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Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation.
Long-Gang Zhao,Zhuo-Ying Li,Guo-Shan Feng,Xiao-Wei Ji,Yu-Ting Tan,Honglan Li,Marc J. Gunter,Yong-Bing Xiang +7 more
TL;DR: This review of prospective studies provides little evidence to support the hypothesis that tea drinking is associated with cancer risk, and more well-designed studies are still needed to identify associations between tea intake and rare cancers.
Journal ArticleDOI
Genetic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease
TL;DR: In this paper , the authors examined genetic correlation between depression and AD using linkage disequilibrium score regression and found that depression had a causal role in AD through Mendelian randomization.
Journal ArticleDOI
Evidence for deprescription in primary care through an umbrella review.
Antonio Olry de Labry Lima,Antonio Olry de Labry Lima,Jorge Marcos Marcos,Jorge Marcos Marcos,Alfonso Marquina Márquez,Alfonso Marquina Márquez,María de los Ángeles González Vera,Antonio Matas Hoces,Clara Bermúdez Tamayo,Clara Bermúdez Tamayo +9 more
TL;DR: The aim of the present study is to summarise available evidence on the effectiveness of deprescription interventions in primary care, and to describe the barriers and enablers of the process from the point of view of patients and healthcare professionals.
Journal ArticleDOI
Systematic evaluation of the associations between mental disorders and dementia: An umbrella review of systematic reviews and meta-analyses.
TL;DR: Wang et al. as discussed by the authors conducted an umbrella review to assess the risk of dementia in patients with eight mental disorders, including anxiety disorder, bipolar disorder, depression, post-traumatic stress disorder, schizophrenia, and sleep disorder.
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What Do We Know about Social and Non-Social Factors Influencing the Pathway from Cognitive Health to Dementia? A Systematic Review of Reviews
M. Lenart-Bugla,Mateusz Łuc,Marcin Pawłowski,Dorota Szcześniak,Imke Seifert,Henrik Wiegelmann,Ansgar Gerhardus,Karin Wolf-Ostermann,Etiënne A. J. A. Rouwette,M. Arfan Ikram,Henry Brodaty,Yun-Hee Jeon,Jane Maddock,Anna Marseglia,René J. F. Melis,Suraj Samtani,Hui-Xin Wang,Anna-Karin Welmer,Myrra Vernooij-Dassen,Joanna Rymaszewska +19 more
TL;DR: A systematic review of reviews provides a comprehensive synthesis of those factors associated with cognition in the context of dementia, identifying the role of social aspects and evidencing knowledge gaps in this area of research.
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