Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses
Vanesa Bellou,Lazaros Belbasis,Ioanna Tzoulaki,Ioanna Tzoulaki,Lefkos T. Middleton,John P. A. Ioannidis,Evangelos Evangelou,Evangelos Evangelou +7 more
TLDR
Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors.Abstract:
Introduction Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. Methods We searched PubMed to identify meta-analyses of observational studies that examined associations between nongenetic factors and dementia. We estimated the summary effect size using random-effects and fixed-effects model, the 95% CI, and the 95% prediction interval. We assessed the between-study heterogeneity (I-square), evidence of small-study effects, and excess significance. Results A total of 76 unique associations were examined. By applying standardized criteria, seven associations presented convincing evidence. These associations pertained to benzodiazepines use, depression at any age, late-life depression, and frequency of social contacts for all types of dementia; late-life depression for Alzheimer's disease; and type 2 diabetes mellitus for vascular dementia and Alzheimer's disease. Discussion Several risk factors present substantial evidence for association with dementia and should be assessed as potential targets for interventions, but these associations may not necessarily be causal.read more
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Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Maria Kyrgiou,Maria Kyrgiou,Ilkka Kalliala,Georgios Markozannes,Marc J. Gunter,Evangelos Paraskevaidis,Hani Gabra,Hani Gabra,Pierre Martin-Hirsch,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis +10 more
TL;DR: Obesity is becoming one of the biggest problems in public health; evidence on the strength of the associated risks may allow finer selection of those at higher risk of cancer, who could be targeted for personalised prevention strategies.
Journal ArticleDOI
What Causes Psychosis? An Umbrella Review of Risk and Protective Factors
Joaquim Radua,Joaquim Radua,Valentina Ramella-Cravaro,Valentina Ramella-Cravaro,John P. A. Ioannidis,Abraham Reichenberg,Nacharin Phiphopthatsanee,Taha Amir,Hyi Yenn Thoo,Dominic Oliver,Cathy Davies,Craig Morgan,Craig Morgan,Philip McGuire,Philip McGuire,Robin M. Murray,Robin M. Murray,Paolo Fusar-Poli,Paolo Fusar-Poli,Paolo Fusar-Poli +19 more
TL;DR: Several factors are found to be associated with psychotic disorders with different levels of evidence and represent a starting point for further etiopathological research and for the improvement of the prediction of psychosis.
Journal ArticleDOI
Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.
Vanesa Bellou,Lazaros Belbasis,Ioanna Tzoulaki,Ioanna Tzoulaki,Evangelos Evangelou,Evangelos Evangelou +5 more
TL;DR: A healthy lifestyle pattern could lead to decreased risk for T2DM, and future randomized clinical trials should focus on identifying efficient strategies to modify harmful daily habits and predisposing dietary patterns.
Journal ArticleDOI
Ten simple rules for conducting umbrella reviews
Paolo Fusar-Poli,Joaquim Radua +1 more
TL;DR: A critical educational review of published umbrella reviews is presented, focusing on the essential practical steps required to produce robust umbrella reviews in the medical field, and 10 key points to consider for conducting robust umbrella Reviews are discussed.
Journal ArticleDOI
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
Piotr Lewczuk,Peter Riederer,Sid E. O'Bryant,Marcel M. Verbeek,Bruno Dubois,Pieter Jelle Visser,Kurt A. Jellinger,Sebastiaan Engelborghs,Alfredo Ramirez,Lucilla Parnetti,Clifford R. Jack,Charlotte E. Teunissen,Harald Hampel,Alberto Lleó,Frank Jessen,Lidia Glodzik,Mony J. de Leon,Anne M. Fagan,José Luis Molinuevo,Willemijn J. Jansen,Bengt Winblad,Leslie M. Shaw,Ulf Andreasson,Markus Otto,Brit Mollenhauer,Jens Wiltfang,Martin R Turner,Inga Zerr,Ron Handels,Alexander G. Thompson,Gunilla Johansson,Natalia Ermann,John Q. Trojanowski,Ilker Karaca,Holger Wagner,Patrick Oeckl,Linda J C van Waalwijk van Doorn,Maria Bjerke,Dimitrios Kapogiannis,H. Bea Kuiperij,Lucia Farotti,Yi Li,Brian A. Gordon,Stéphane Epelbaum,Stephanie J.B. Vos,Catharina J.M. Klijn,William E. Van Nostrand,Carolina Minguillon,Matthias Schmitz,Carla Gallo,Andrea Lopez Mato,Florence Thibaut,Simone Lista,Daniel Alcolea,Henrik Zetterberg,Kaj Blennow,Johannes Kornhuber +56 more
TL;DR: In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes the opportunity to extend and update the original paper.
References
More filters
Journal ArticleDOI
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu,Tiia Ngandu,Jenni Lehtisalo,Alina Solomon,Alina Solomon,Esko Levälahti,Satu Ahtiluoto,Riitta Antikainen,Lars Bäckman,Tuomo Hänninen,Antti Jula,Tiina Laatikainen,Tiina Laatikainen,Jaana Lindström,Francesca Mangialasche,Teemu Paajanen,Satu Pajala,Markku Peltonen,Rainer Rauramaa,Anna Stigsdotter-Neely,Timo E. Strandberg,Timo E. Strandberg,Jaakko Tuomilehto,Hilkka Soininen,Miia Kivipelto +24 more
TL;DR: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, the authors aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.
Journal ArticleDOI
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
Sam Norton,Fiona E. Matthews,Deborah E. Barnes,Deborah E. Barnes,Kristine Yaffe,Carol Brayne +5 more
TL;DR: Around a third of Alzheimer's diseases cases worldwide might be attributable to potentially modifiable risk factors, and Alzheimer's disease incidence might be reduced through improved access to education and use of effective methods targeted at reducing the prevalence of vascular risk factors.
Journal ArticleDOI
A re-evaluation of random-effects meta-analysis
TL;DR: It is suggested that random-effects meta-analyses as currently conducted often fail to provide the key results, and the extent to which distribution-free, classical and Bayesian approaches can provide satisfactory methods is investigated.
Journal ArticleDOI
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Lars Bertram,Matthew B. McQueen,Matthew B. McQueen,Kristina Mullin,Deborah Blacker,Rudolph E. Tanzi +5 more
TL;DR: A publicly available, continuously updated database that comprehensively catalogs all genetic association studies in the field of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases.
Journal ArticleDOI
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
TL;DR: The majority of community-dwelling older persons have brain pathology, and those with dementia most often have multiple brain pathologies, which greatly increases the odds of dementia.