Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses
Vanesa Bellou,Lazaros Belbasis,Ioanna Tzoulaki,Ioanna Tzoulaki,Lefkos T. Middleton,John P. A. Ioannidis,Evangelos Evangelou,Evangelos Evangelou +7 more
TLDR
Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors.Abstract:
Introduction Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. Methods We searched PubMed to identify meta-analyses of observational studies that examined associations between nongenetic factors and dementia. We estimated the summary effect size using random-effects and fixed-effects model, the 95% CI, and the 95% prediction interval. We assessed the between-study heterogeneity (I-square), evidence of small-study effects, and excess significance. Results A total of 76 unique associations were examined. By applying standardized criteria, seven associations presented convincing evidence. These associations pertained to benzodiazepines use, depression at any age, late-life depression, and frequency of social contacts for all types of dementia; late-life depression for Alzheimer's disease; and type 2 diabetes mellitus for vascular dementia and Alzheimer's disease. Discussion Several risk factors present substantial evidence for association with dementia and should be assessed as potential targets for interventions, but these associations may not necessarily be causal.read more
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Self‐reported cognitive decline among middle and older age autistic adults
Claire B. Klein,Goldie A. McQuaid,Rebecca A. Charlton,Laura Grofer Klinger,Gregory L. Wallace +4 more
TL;DR: This article found high rates of cognitive decline with 30% of the sample screening positive for cognitive decline in middle and older age autistic adults, with the most common symptoms being declining interest in leisure activities and increases in everyday problems with thinking, memory and judgment.
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Healthy Diet and Risk of Dementia in Older Adults—Reply
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Association of body mass index and dietary intake with mild cognitive impairment and dementia: a retrospective cohort study
Apisit Manacharoen,Kulapong Jayanama,Sirasa Ruangritchankul,Prin Vathesatogkit,Piyamitr Sritara,Daruneewan Warodomwichit +5 more
TL;DR: In this paper , the authors evaluated the association of body mass index (BMI) and dietary intake with the risk of mild cognitive impairment (MCI) and dementia in older adults.
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Do Personality Traits Influence the Association Between Depression and Dementia in Old Age?
Adeleye Adaralegbe,H. Egbuchiem,O M Adeoti,Khuzeman Abbasi,Esther Ezeani,Ngozi J Adaralegbe,Abdulraheem Olaide Babarinde,Maureen G Boms,Chidiebube Nzeako,Olumide Ayeni +9 more
TL;DR: In this article , the authors explored the influence of personality traits on the association between change in depression and dementia in old age and found that personality traits, overall, did not influence how depression predicts the development of dementia.
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Representation of racial and ethnic minority groups in cohort studies evaluating risk factors for dementia: protocol for a scoping review.
TL;DR: In this paper, a systematic investigation and quantification of racial and ethnic minority representation in dementia risk factor research has been conducted using a comprehensive framework to assess racial/ethnic minority representation.
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