Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses
Vanesa Bellou,Lazaros Belbasis,Ioanna Tzoulaki,Ioanna Tzoulaki,Lefkos T. Middleton,John P. A. Ioannidis,Evangelos Evangelou,Evangelos Evangelou +7 more
TLDR
Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors.Abstract:
Introduction Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. Methods We searched PubMed to identify meta-analyses of observational studies that examined associations between nongenetic factors and dementia. We estimated the summary effect size using random-effects and fixed-effects model, the 95% CI, and the 95% prediction interval. We assessed the between-study heterogeneity (I-square), evidence of small-study effects, and excess significance. Results A total of 76 unique associations were examined. By applying standardized criteria, seven associations presented convincing evidence. These associations pertained to benzodiazepines use, depression at any age, late-life depression, and frequency of social contacts for all types of dementia; late-life depression for Alzheimer's disease; and type 2 diabetes mellitus for vascular dementia and Alzheimer's disease. Discussion Several risk factors present substantial evidence for association with dementia and should be assessed as potential targets for interventions, but these associations may not necessarily be causal.read more
Citations
More filters
Journal ArticleDOI
Impact of benzodiazepine consumption reduction on future burden of dementia
Hélène Jacqmin-Gadda,Florian Guillet,Clément Mathieu,Catherine Helmer,Antoine Pariente,Pierre Joly +5 more
TL;DR: A modest but significant reduction in future dementia burden could be obtained by applying current recommendation for duration of benzodiazepine use, using a Monte Carlo approach based on an illness-death model.
Journal ArticleDOI
The role of diet on the risk of dementia in the oldest old: The Monzino 80-plus population-based study.
Cristina Nicoli,Alessia A. Galbussera,Cristina Bosetti,Carlotta Franchi,Silvano Gallus,Sara Mandelli,Gabriella Marcon,Gabriella Marcon,Pierluigi Quadri,Patrizia Riso,Emma Riva,Ugo Lucca,Mauro Tettamanti +12 more
TL;DR: In this article, the authors analyzed data from the Monzino 80-plus study, a population-based study in subjects 80 years or older in the Varese province, Italy.
Journal ArticleDOI
Dietary protein and multiple health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
Jiale Lv,Qijun Wu,Xin-Yu Li,Chang Gao,Ming-zhu Xu,Juan Yang,Siwen Zang,Jie Luan,Dong-Zhen Cai,Qing Chang,Yuhong Zhao +10 more
TL;DR: In this paper , the authors conducted a systematic review on the relationship between the intake of dietary proteins and multiple health outcomes, including type 2 diabetes, all-cause mortality, and risk of cardiovascular disease mortality.
Journal ArticleDOI
Identification of Demographic Variables Influencing Dementia Literacy and Risk Perception Through a Global Survey.
Becky R. Horst,Joyla A. Furlano,Michelle Y. S. Wong,Sabrina D. Ford,Brenna B. Han,Lindsay S. Nagamatsu +5 more
TL;DR: In this paper, the authors investigate dementia literacy and how demographic characteristics influence these perceptions in order to provide evidence for how dementia-centered public health initiatives should structure their focus, and find that women, older adults, those with non-post-secondary attainment, below average income, and White background tended to report lower risk scores.
Journal ArticleDOI
Risk and protective factors for alcohol and tobacco related disorders: An umbrella review of observational studies
Marco Solmi,Marco Solmi,Serena Civardi,Roberto Corti,John Anil,Jacopo Demurtas,Shannon Lange,Joaquim Radua,Joaquim Radua,Joaquim Radua,Elena Dragioti,Paolo Fusar-Poli,Paolo Fusar-Poli,Paolo Fusar-Poli,Andre F. Carvalho,Andre F. Carvalho +15 more
TL;DR: Few risk factors identified at-risk groups where selective preventative strategies could be developed to prevent AUD/TUD, with convincing evidence emerged for parental alcohol supply, and impulsivity traits in college students for AUD, and attention-deficit/hyperactivity disorder for TUD.
References
More filters
Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.