Journal ArticleDOI
Targeted contrast agents for magnetic resonance imaging and ultrasound.
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TLDR
The development of contrast agents that can be localized to a particular tissue or cellular epitope will potentially allow the noninvasive visualization and characterization of a variety of disease states as mentioned in this paper.About:
This article is published in Current Opinion in Biotechnology.The article was published on 2005-02-01. It has received 208 citations till now. The article focuses on the topics: Molecular imaging & Microbubbles.read more
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
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Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.
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Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
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Nanomedicine--challenge and perspectives.
Kristina Riehemann,Stefan W. Schneider,Thomas A. Luger,Biana Godin,Mauro Ferrari,Harald Fuchs +5 more
TL;DR: This Review gives an overview of selected recent developments and applications of nanomedicine.
References
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Journal ArticleDOI
In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
Dara L. Kraitchman,Alan W. Heldman,Ergin Atalar,Ergin Atalar,Luciano C. Amado,Bradley J. Martin,Mark F. Pittenger,Joshua M. Hare,Jeff W.M. Bulte +8 more
TL;DR: MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of M SCs in MI.
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Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With αvβ3-Integrin–Targeted Nanoparticles
Patrick M. Winter,Anne M. Morawski,Shelton D. Caruthers,Ralph W. Fuhrhop,Huiying Zhang,Todd A. Williams,John S. Allen,Elizabeth K. Lacy,J. David Robertson,Gregory M. Lanza,Samuel A. Wickline +10 more
TL;DR: This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies.
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Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents.
Joseph A. Frank,Brad Miller,Ali S. Arbab,Holly A. Zywicke,E. Kay Jordan,Bobbi K. Lewis,L. Henry Bryant,Jeff W.M. Bulte +7 more
TL;DR: Magnetic labeling of mammalian cells with use of ferumoxides and TAs is possible and may enable cellular MR imaging and tracking in experimental and clinical settings.
Journal ArticleDOI
Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to αvβ3
Dilantha B. Ellegala,Howard Leong-Poi,Joan E. Carpenter,Alexander L. Klibanov,Sanjiv Kaul,Mark E. Shaffrey,Jiri Sklenar,Jonathan R. Lindner +7 more
TL;DR: CEU with microbubbles targeted to &agr;v&bgr;3 can noninvasively detect early tumor angiogenesis and, when coupled with changes in blood volume and velocity, may provide insights into the biology of tumor Angiogenesis.
Journal Article
Molecular Imaging of Angiogenesis in Nascent Vx-2 Rabbit Tumors Using a Novel ανβ3-targeted Nanoparticle and 1.5 Tesla Magnetic Resonance Imaging
Patrick M. Winter,Shelton D. Caruthers,Andrea Kassner,Thomas D. Harris,Lori Chinen,John S. Allen,Elizabeth K. Lacy,Huiying Zhang,J. David Robertson,Samuel A. Wickline,Gregory M. Lanza +10 more
TL;DR: The first in vivo use of a magnetic resonance (MR) molecular imaging nanoparticle to sensitively detect and spatially characterize neovascularity induced by implantation of the rabbit Vx-2 tumor using a common clinical field strength is reported.