Journal ArticleDOI
The anatomy of memory : an interactive overview of the parahippocampal-hippocampal network
Reads0
Chats0
TLDR
An interactive diagram is developed with the aim to display all of the currently known anatomical connections of the rat parahippocampal–hipp hippocampal network and discuss the functional implications of some relatively underexposed connections.Abstract:
Converging evidence suggests that each parahippocampal and hippocampal subregion contributes uniquely to the encoding, consolidation and retrieval of declarative memories, but their precise roles remain elusive. Current functional thinking does not fully incorporate the intricately connected networks that link these subregions, owing to their organizational complexity; however, such detailed anatomical knowledge is of pivotal importance for comprehending the unique functional contribution of each subregion. We have therefore developed an interactive diagram with the aim to display all of the currently known anatomical connections of the rat parahippocampal-hippocampal network. In this Review, we integrate the existing anatomical knowledge into a concise description of this network and discuss the functional implications of some relatively underexposed connections.read more
Citations
More filters
Journal ArticleDOI
Functional organization of the hippocampal longitudinal axis
TL;DR: Together, anatomical studies and electrophysiological recordings in rodents suggest a model in which functional long-axis gradients are superimposed on discrete functional domains, which provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
Journal ArticleDOI
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan Mark,Yves Agid,Martin Brüne,Edward T. Bullmore,Cameron S. Carter,Nicola S. Clayton,Richard C. Connor,Sabrina Davis,Bill Deakin,Robert J. DeRubeis,Bruno Dubois,Mark A. Geyer,Guy M. Goodwin,Philip Gorwood,Thérèse M. Jay,Marian Joëls,Isabelle M. Mansuy,Andreas Meyer-Lindenberg,Declan G. Murphy,Edmund T. Rolls,Bernd Saletu,Michael Spedding,John A. Sweeney,Miles A. Whittington,Larry J. Young +24 more
TL;DR: This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Journal ArticleDOI
A pathophysiological framework of hippocampal dysfunction in ageing and disease
TL;DR: Observations in the context of the functional and molecular organization of the hippocampal circuit give rise to a unified pathophysiological framework of hippocampal dysfunction.
Journal ArticleDOI
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods
Ingmar Blümcke,Maria Thom,Eleonora Aronica,Dawna D. Armstrong,Fabrice Bartolomei,Andrea Bernasconi,Neda Bernasconi,Christian G. Bien,Fernando Cendes,Roland Coras,J. Helen Cross,Thomas S. Jacques,Philippe Kahane,Gary W. Mathern,Haijme Miyata,Solomon L. Moshé,Solomon L. Moshé,Buge Oz,Cigdem Ozkara,Emilio Perucca,Sanjay M. Sisodiya,Samuel Wiebe,Roberto Spreafico +22 more
TL;DR: The proposed international consensus classification of hippocampal neuronal cell loss will aid in the characterization of specific clinicopathologic syndromes, and explore variability in imaging and electrophysiology findings, and in postsurgical seizure control.
Journal ArticleDOI
The hippocampal CA2 region is essential for social memory
TL;DR: CA2, a relatively small area interposed between CA3 and CA1 that forms the nexus of a powerful disynaptic circuit linking EC input with CA1 output, is revealed as a critical hub of sociocognitive memory processing.
References
More filters
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Journal ArticleDOI
Neuronal Oscillations in Cortical Networks
György Buzsáki,Andreas Draguhn +1 more
TL;DR: Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
Journal ArticleDOI
The medial temporal lobe
TL;DR: This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.