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Journal ArticleDOI

The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip

TLDR
The iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution and showed high selectivity towards arsenic ions over other metal ions.
Abstract
In this work, the iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution. The assay achieved a detection limit of 7.6 nM (ca. 0.57 μg L-1) and showed high selectivity towards arsenic ions over other metal ions. Additionally, the assay could function in natural water and a simple microfluidic chip was used to investigate the potential of this platform for real-time detection.

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Citations
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Journal ArticleDOI

Nanomaterial-based aptamer sensors for arsenic detection

TL;DR: The recent development and applications of aptamer sensors (aptasensors) based-on nanomaterial for arsenic detection are reviewed, in particular with emphasis on the works using optical and electrochemical technologies.
Journal ArticleDOI

Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.

TL;DR: This review of works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test highlights the detection of nucleic acids at the point of care as an emerging application of inorganic Chemistry.
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An electrochemiluminescence cloth-based biosensor with smartphone-based imaging for detection of lactate in saliva.

TL;DR: The presented ECL platform has the potential to be applied to non-invasively detect a variety of analytes of medical interest, and the ECL biosensor is successfully applied for the determination of lactate in human saliva.
Journal ArticleDOI

Green synthesis of surface-passivated carbon dots from the prickly pear cactus as a fluorescent probe for the dual detection of arsenic( iii ) and hypochlorite ions from drinking water

TL;DR: In this article, a simple sensor based on Glutathione (GSH) was developed for the green synthesis of surface-passivated carbon dots from edible prickly pear cactus fruit as the carbon source by a one-pot hydrothermal route.
Journal ArticleDOI

Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA.

TL;DR: The ratiometric fluorescence nanoprobe constructed in this work exhibited high sensitivity for ssab (a dsDNA) and c-myc (a parallel G4) with a low detection limit of 0.90 and 3.31 nM, respectively and showed good selectivity to parallel G-quadruplex (G4) and double-stranded (ds) DNA over antiparallel G4 and single- Stranded DNA.
References
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Journal ArticleDOI

Phosphorescent chemosensors based on heavy-metal complexes

TL;DR: This critical review focuses on the design principles and the recent development of phosphorescent chemosensors for metal cations, anions, pH, oxygen, volatile organic compounds and biomolecules based on some heavy-metal complexes.
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Phosphorescent heavy-metal complexes for bioimaging

TL;DR: This critical review systematically evaluates the advantages of phosphorescent heavy-metal complexes as bioimaging probes, including their photophysical properties, cytotoxicity and cellular uptake mechanisms.
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Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

TL;DR: A set of ligand-binding DNA sequences are isolated from a large pool of random sequence DNAs by selection and amplification in vitro, revealing that ligand binding is DNA-specific; RNAs of identical sequence could not interact with the same ligands.
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Applications of Aptamers as Sensors

TL;DR: Aptamers are ligand-binding nucleic acids whose affinities and selectivities can rival those of antibodies, and they are readily adapted to sequence- (and hence signal-) amplification methods.
Journal ArticleDOI

Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach.

TL;DR: This Account summarizes the recent efforts to develop aptamers through cell-SELEX for the study of cancer and apply them in cancer diagnosis and therapy and demonstrates how molecular assemblies can integrate the properties of aptamer probes and, for example, nanoparticles or microfluidic devices, to improve cancer cell enrichment, detection and therapy.
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