Journal ArticleDOI
The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip
Sheng Lin,Wanhe Wang,Chong Hu,Guan-Jun Yang,Chung-Nga Ko,Kangning Ren,Chung-Hang Leung,Dik-Lung Ma +7 more
TLDR
The iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution and showed high selectivity towards arsenic ions over other metal ions.Abstract:
In this work, the iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution. The assay achieved a detection limit of 7.6 nM (ca. 0.57 μg L-1) and showed high selectivity towards arsenic ions over other metal ions. Additionally, the assay could function in natural water and a simple microfluidic chip was used to investigate the potential of this platform for real-time detection.read more
Citations
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Journal ArticleDOI
Nanomaterial-based aptamer sensors for arsenic detection
TL;DR: The recent development and applications of aptamer sensors (aptasensors) based-on nanomaterial for arsenic detection are reviewed, in particular with emphasis on the works using optical and electrochemical technologies.
Journal ArticleDOI
Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.
Christine F. Markwalter,Andrew G. Kantor,Carson Paige Moore,Kelly A. Richardson,David W. Wright +4 more
TL;DR: This review of works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test highlights the detection of nucleic acids at the point of care as an emerging application of inorganic Chemistry.
Journal ArticleDOI
An electrochemiluminescence cloth-based biosensor with smartphone-based imaging for detection of lactate in saliva.
TL;DR: The presented ECL platform has the potential to be applied to non-invasively detect a variety of analytes of medical interest, and the ECL biosensor is successfully applied for the determination of lactate in human saliva.
Journal ArticleDOI
Green synthesis of surface-passivated carbon dots from the prickly pear cactus as a fluorescent probe for the dual detection of arsenic( iii ) and hypochlorite ions from drinking water
TL;DR: In this article, a simple sensor based on Glutathione (GSH) was developed for the green synthesis of surface-passivated carbon dots from edible prickly pear cactus fruit as the carbon source by a one-pot hydrothermal route.
Journal ArticleDOI
Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA.
TL;DR: The ratiometric fluorescence nanoprobe constructed in this work exhibited high sensitivity for ssab (a dsDNA) and c-myc (a parallel G4) with a low detection limit of 0.90 and 3.31 nM, respectively and showed good selectivity to parallel G-quadruplex (G4) and double-stranded (ds) DNA over antiparallel G4 and single- Stranded DNA.
References
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Journal ArticleDOI
Assembly of palladium(II) and platinum(II) metallo-rectangles with a guanosine-substituted terpyridine and study of their interactions with quadruplex DNA.
Sushobhan Ghosh,Oscar Mendoza,Leticia Cubo,Frédéric Rosu,Valérie Gabelica,Andrew J. P. White,Ramon Vilar +6 more
TL;DR: These studies have shown that both these assemblies interact selectively with quadruplex DNA (human telomeric DNA and the G-rich promoter region of c-myc oncogene) over duplex DNA, and are able to induce dimerization of parallel G-quadruplex structures.
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Combination of i‐Motif and G‐Quadruplex Structures within the Same Strand: Formation and Application
Jun Zhou,Samir Amrane,Samir Amrane,Dursun Nizam Korkut,Dursun Nizam Korkut,Anne Bourdoncle,Anne Bourdoncle,Hong-Zhang He,Dik-Lung Ma,Jean-Louis Mergny,Jean-Louis Mergny +10 more
TL;DR: A double quadruplex composed of an i-motif and a G-quadruplex was constructed within one oligonucleotide strand, which can serve as a NOTIF logic gate on the basis of the fluorescence of crystal violet.
Journal ArticleDOI
Specific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditions
Li-Na Zhu,Bin Wu,De-Ming Kong +2 more
TL;DR: TMPipEOPP, a cationic porphyrin derivative designed by us, was demonstrated as a promising multimeric telomeric G-quadruplex ligand under molecular crowding conditions and introduces a new route for screening anticancer drugs targeting telomerics G- quadruplexes.
Journal ArticleDOI
G-quadruplex recognition by bis-indole carboxamides
TL;DR: The de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative are reported, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
Journal ArticleDOI
A simple and sensitive fluorimetric aptasensor for the ultrasensitive detection of arsenic(III) based on cysteamine stabilized CdTe/ZnS quantum dots aggregation.
TL;DR: The interference effect of a wide variety of cations and anions was investigated, and the obtained results confirm high selectivity of the aptasensor for As(III) detection.