Journal ArticleDOI
The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip
Sheng Lin,Wanhe Wang,Chong Hu,Guan-Jun Yang,Chung-Nga Ko,Kangning Ren,Chung-Hang Leung,Dik-Lung Ma +7 more
TLDR
The iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution and showed high selectivity towards arsenic ions over other metal ions.Abstract:
In this work, the iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution. The assay achieved a detection limit of 7.6 nM (ca. 0.57 μg L-1) and showed high selectivity towards arsenic ions over other metal ions. Additionally, the assay could function in natural water and a simple microfluidic chip was used to investigate the potential of this platform for real-time detection.read more
Citations
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Journal ArticleDOI
Nanomaterial-based aptamer sensors for arsenic detection
TL;DR: The recent development and applications of aptamer sensors (aptasensors) based-on nanomaterial for arsenic detection are reviewed, in particular with emphasis on the works using optical and electrochemical technologies.
Journal ArticleDOI
Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.
Christine F. Markwalter,Andrew G. Kantor,Carson Paige Moore,Kelly A. Richardson,David W. Wright +4 more
TL;DR: This review of works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test highlights the detection of nucleic acids at the point of care as an emerging application of inorganic Chemistry.
Journal ArticleDOI
An electrochemiluminescence cloth-based biosensor with smartphone-based imaging for detection of lactate in saliva.
TL;DR: The presented ECL platform has the potential to be applied to non-invasively detect a variety of analytes of medical interest, and the ECL biosensor is successfully applied for the determination of lactate in human saliva.
Journal ArticleDOI
Green synthesis of surface-passivated carbon dots from the prickly pear cactus as a fluorescent probe for the dual detection of arsenic( iii ) and hypochlorite ions from drinking water
TL;DR: In this article, a simple sensor based on Glutathione (GSH) was developed for the green synthesis of surface-passivated carbon dots from edible prickly pear cactus fruit as the carbon source by a one-pot hydrothermal route.
Journal ArticleDOI
Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA.
TL;DR: The ratiometric fluorescence nanoprobe constructed in this work exhibited high sensitivity for ssab (a dsDNA) and c-myc (a parallel G4) with a low detection limit of 0.90 and 3.31 nM, respectively and showed good selectivity to parallel G-quadruplex (G4) and double-stranded (ds) DNA over antiparallel G4 and single- Stranded DNA.
References
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Journal ArticleDOI
Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes
TL;DR: A new cationic porphyrin derivative, m-TMPipEOPP, was synthesized and characterized, and its multimeric G-quadruplex recognition specificity under molecular crowding conditions was compared to its isomers.
Journal ArticleDOI
Aptamer conjugated silver nanoparticles for the colorimetric detection of arsenic ions using response surface methodology
TL;DR: In this article, aptamer conjugated silver nanoparticles (Apt-SNPs) were synthesized and studied for colorimetric sensing of As(III) ions in solution.
Journal ArticleDOI
Label-free signal-on aptasensor for sensitive electrochemical detection of arsenite
Lin Cui,Jie Wu,Huangxian Ju +2 more
TL;DR: A signal-on aptasensor was fabricated for highly sensitive and selective electrochemical detection of arsenite with a label-free Ars-3 aptamer self-assembled on a screen-printed carbon electrode (SPCE) via Au-S bond, showing excellent specificity against other heavy metal ions.
Journal ArticleDOI
A cost-effective fluorescence mini-microscope for biomedical applications
Yu Shrike Zhang,Yu Shrike Zhang,João Ribas,Akhtar Nadhman,Akhtar Nadhman,Akhtar Nadhman,Julio Aleman,Julio Aleman,Šeila Selimović,Šeila Selimović,Sasha Cai Lesher-Perez,Ting Wang,Ting Wang,Ting Wang,Vijayan Manoharan,Vijayan Manoharan,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Alessia Damilano,Alessia Damilano,Nasim Annabi,Nasim Annabi,Nasim Annabi,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Shuichi Takayama,Shuichi Takayama,Ali Khademhosseini +29 more
TL;DR: A miniature microscope, designed and fabricated from off-the-shelf components and a webcam, with built-in fluorescence capability for biomedical applications, which can potentially replace conventional bench-top microscopy where long-term in situ and large-scale imaging/analysis is required.
Journal ArticleDOI
Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA.
TL;DR: It is found that formations of G-quadruplex and i-motif in the two complementary strands are mutually exclusive in a variety of DNA templates, which include human telomere and promoter fragments of hINS and hTERT genes.