The biology of vascular endothelial growth factor
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TLDR
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.Abstract:
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6read more
Citations
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The Role of Epidermal Growth Factor Receptor in Cancer Metastasis and Microenvironment
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Material-based deployment enhances efficacy of endothelial progenitor cells
TL;DR: Results demonstrate that vascular progenitor cell utility is highly dependent on the mode of delivery, and suggest that one can create new vascular beds for a variety of applications with this material-controlled deployment of cells.
The Vesiculo-Vacuolar Organelle (VVO): A New Endothelial Cell
Ann M. Dvorak,Dian Feng +1 more
TL;DR: In this article, a newly defined endothelial cell permeability structure, termed the vesiculo-vuolar organelle (VVO), has been identified in the microvasculature that accompanies tumors, in venules associated with allergic inflammation, and in the endothelia of normal venules.
Journal ArticleDOI
Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress
TL;DR: This review focuses on one aspect of the crossroad between oxidative stress and angiogenesis, namely cycling hypoxia, which represents an important and relatively less well understood feature of tumor biology that requires additional research.
Journal ArticleDOI
Phase I Study of Intravenous Vascular Endothelial Growth Factor Trap, Aflibercept, in Patients With Advanced Solid Tumors
A. Craig Lockhart,Mace L. Rothenberg,Jakob Dupont,Wendy A Cooper,Paul Chevalier,Lars Sternas,Giliane Buzenet,Elizabeth Koehler,Jeffrey A. Sosman,Lawrence H. Schwartz,David H. Gultekin,Jason A. Koutcher,Edwin F. Donnelly,Ric Andal,Isabelle Dancy,David R. Spriggs,William P. Tew +16 more
TL;DR: VEGF Trap was well tolerated at the dose levels tested and pharmacodynamic and pharmacokinetic markers were indicative of VEGF blockade, and the recommended phase II dose is 4 mg/kg every 2 weeks.
References
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Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.