The biology of vascular endothelial growth factor
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TLDR
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.Abstract:
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6read more
Citations
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TRAF6 Upregulates Expression of HIF-1α and Promotes Tumor Angiogenesis
TL;DR: It is shown that TRAF6 upregulates expression of hypoxia-inducible factor (HIF)-1α and promotes tumor angiogenesis and growth.
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Association Between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients
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Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Shalini Bhardwaj,Himadri Roy,Marcin Gruchała,Helena Viita,Ivana Kholová,Ilze Kokina,Marc G. Achen,Steven A. Stacker,Marja Hedman,Kari Alitalo,Seppo Ylä-Herttuala +10 more
TL;DR: The results help to define possibilities for local angiogenic therapy around blood vessels and support the concept thatAngiogenic effects may be tissue-specific and depend both on the growth factor ligands and the target tissues.
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Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer.
Hyun Hee Lee,Young Joon Son,Won Hyeok Lee,Young Woo Park,Seoung Wan Chae,Wha Ja Cho,Young Min Kim,Hye-Jeong Choi,Dae Hwa Choi,Seok Won Jung,Young Joo Min,Soon Eun Park,Byung Ju Lee,Hee Jeong Cha,Jeong Woo Park +14 more
TL;DR: It is demonstrated that TTP acts as a negative regulator of VEGF gene expression in colon cancer cells, suggesting that it can be used as a novel therapeutic agent to treat colon cancer.
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The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines.
TL;DR: VEGF plays a major role in glioma formation and that down-regulation of VEGF, rather than bFGF, would be a more effective choice forglioma gene therapy, according to this study.
References
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Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.