The biology of vascular endothelial growth factor
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TLDR
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.Abstract:
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6read more
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Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism
TL;DR: It is reported that human airway smooth muscle cells express vascular endo‐thelial growth factor (VEGF)121,165,189,206 splice variants and secrete VEGF protein constitutively.
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Regulation of embryonic implantation.
TL;DR: The V EGF gene is one of the earliest genes activated during human preimplantation embryo development, giving rise to the assumption that VEGF is crucial for embryonic development, suggesting a role of this cytokine family during early embryonic development.
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DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating Inflammatory Gene Expression
TL;DR: It is proposed that the DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression, and that pathway defects may contribute to chronic inflammatory disorders.
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Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Yong S. Chang,Lance L. Munn,Mechteld V. Hillsley,Randal O. Dull,Jin Yuan,Sunitha Lakshminarayanan,Thomas W. Gardner,Rakesh K. Jain,John M. Tarbell +8 more
TL;DR: It is indicated that VEGF affects endothelial transport properties differently depending on the vessel type and that differences in cell signaling pathways underlie the differences in V EGF responsiveness.
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Advanced Glycation End Products Induce Blood–Retinal Barrier Dysfunction in Normoglycemic Rats
TL;DR: It is suggested that AGEs can initiate BRB dysfunction in nondiabetic rats and a concomitant increase in retinal VEGF expression and this findings may have implications for the role of A GEs in the pathogenesis of diabetic retinopathy.
References
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Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
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What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.