The biology of vascular endothelial growth factor
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TLDR
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.Abstract:
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6read more
Citations
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IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Jonathan Corne,Geoffrey L. Chupp,Chun Guen Lee,Robert J. Homer,Zhou Zhu,Qingsheng Chen,Bing Ma,Yuefen Du,Francoise Roux,John R. McArdle,Aaron B. Waxman,Aaron B. Waxman,Jack A. Elias +12 more
TL;DR: IL-13 has protective effects in hyperoxic acute lung injury, and it is demonstrated that IL-13, alone and in combination with 100% (2), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL- 13 are mediated, in part, by VEGf.
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Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells: role in the functional and morphological alterations of peritoneal membranes in peritoneal dialysis.
Reiko Inagi,Toshio Miyata,Takashi Yamamoto,Daisuke Suzuki,Ken Ichi Urakami,Akira Saito,Charles van Ypersele de Strihou,Kiyoshi Kurokawa +7 more
TL;DR: GDPs in PD fluids stimulate the production of vascular endothelial growth factor (VEGF), a factor known to enhance vascular permeability and angiogenesis, and VEGF production induced by GDPs may play a role in the progressive deterioration of the peritoneal membrane.
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Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance.
Vinay K. Gupta,Nora Jaskowiak,Michael A. Beckett,Helena J. Mauceri,Jeremy Grunstein,Randall S. Johnson,Douglas P. Calvin,Edwardine Nodzenski,Marija Pejovic,Donald Kufe,Mitchell C. Posner,Ralph R. Weichselbaum +11 more
TL;DR: These findings represent the first genetic evidence that factors other than inherent tumor cell radiosensitivity are important determinants of radiocurability.
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Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.
Alicja Jozkowicz,John P. Cooke,Ibeth Guevara,Ihor Huk,Philip Funovics,Otmar Pachinger,Franz Weidinger,Jozef Dulak,Jozef Dulak +8 more
TL;DR: These studies reveal that NO derived from NO-donors or generated by NOS within the cells, upregulates the synthesis of VEGF in vascular smooth muscle cells, an alternative approach in therapeutic angiogenesis.
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Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
Joseph B. Kearney,Carrie A. Ambler,Kelli Ann Monaco,Natalie Johnson,Rebecca Rapoport,Victoria L. Bautch +5 more
TL;DR: The results support a model whereby aberrant endothelial cell division is the cellular mechanism resulting in vascular overgrowth, and they suggest that VEGF-dependent endothelialcell division is normally finely modulated by flt-1 to produce blood vessels.
References
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Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
Journal ArticleDOI
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.