The biology of vascular endothelial growth factor
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TLDR
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.Abstract:
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6read more
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Verteporfin plus Ranibizumab for Choroidal Neovascularization in Age-related Macular Degeneration: Twelve-month MONT BLANC Study Results
Michael Larsen,Ursula Schmidt-Erfurth,Paolo Lanzetta,Sebastian Wolf,Christian Simader,Erika Tokaji,Stefan Pilz,Annemarie Weisberger +7 more
TL;DR: The combination PRN treatment regimen with verteporfin PDT and ranibizumab was effective in achieving BCVA gain comparable with ranibZumab monotherapy; however, the study did not show benefits with respect to reducing the number of ranibzumab retreatment over 12 months.
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Bombesin Stimulates Nuclear Factor κB Activation and Expression of Proangiogenic Factors in Prostate Cancer Cells
Lyuba Levine,Joseph A. Lucci,Barbara Pazdrak,Ji Zhong Cheng,Yan Shi Guo,Courtney M. Townsend,Mark R. Hellmich +6 more
TL;DR: A role for BBS and GRP-R is demonstrated in the NF kappa B-dependent up-regulation of proangiogenic gene expression, and a possible molecular mechanism linking NE differentiation and the increased metastatic potential of androgen-insensitive prostate cancers is suggested.
Journal ArticleDOI
A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200
TL;DR: High-dose bevacizumab added to IFL is a well-tolerated and highly active regimen in patients with previously untreated metastatic colorectal cancer.
Journal ArticleDOI
Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors
TL;DR: Two phase III randomized controlled clinical trials of such an inhibitor are now in progress, attempting to evaluate the efficacy of this approach to preventing the progression, or inducing regression, of "nonclinically significant" diabetic macular edema and of severe nonproliferative diabetic retinopathy.
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G-quadruplex-based aptamers against protein targets in therapy and diagnostics
Chiara Platella,Claudia Riccardi,Daniela Montesarchio,Giovanni N. Roviello,Domenica Musumeci +4 more
TL;DR: Recent advancements in SELEX technology for the efficient and rapid identification of new candidate aptamers (introduction of microfluidic systems and next generation sequencing) and discovery of several G4-forming motifs in important regulatory regions of the human or viral genome bound by endogenous proteins are reviewed.
References
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Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
Journal ArticleDOI
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.