Journal ArticleDOI
The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.
Shu-Hua Xiao,Bin Zhan,Jian Xue,Gaddam Goud,Alex Loukas,Yueyuan Liu,Angela L. Williamson,Sen Liu,Vehid Deumic,Peter J. Hotez +9 more
TLDR
Data on the worm burden reductions afforded by these hookworm antigens approximate the level of protection reported previously from dogs challenged with A. caninum L3, and provide additional evidence to support these hookworms antIGens as vaccine candidates for human hookworm infection.About:
This article is published in Experimental Parasitology.The article was published on 2008-01-01. It has received 81 citations till now. The article focuses on the topics: Necator americanus & Hookworm vaccine.read more
Citations
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Journal ArticleDOI
The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer
Banchob Sripa,Paul J. Brindley,Jason Mulvenna,Thewarach Laha,Michael J. Smout,Eimorn Mairiang,Jeffrey M. Bethony,Alex Loukas +7 more
TL;DR: A schema for human disease progression from fluke infection, chronic opisthorchiasis, advanced periductal fibrosis, and cholangiocarcinogenesis is reviewed, and a rationale for biomarker discovery to facilitate early intervention is presented.
Journal ArticleDOI
Developing vaccines to combat hookworm infection and intestinal schistosomiasis.
Peter J. Hotez,Jeffrey M. Bethony,Jeffrey M. Bethony,David Diemert,David Diemert,Mark S. Pearson,Alex Loukas +6 more
TL;DR: Recent progress in the field of hookworm infection and schistosomiasis is described and the rationale for vaccine development is described.
Journal ArticleDOI
Genome of the human hookworm Necator americanus
Yat T. Tang,Xin Gao,Bruce A. Rosa,Sahar Abubucker,Kymberlie Hallsworth-Pepin,John Martin,Rahul Tyagi,Esley M. Heizer,Xu Zhang,Veena Bhonagiri-Palsikar,Patrick Minx,Wesley C. Warren,Qi Wang,Bin Zhan,Peter J. Hotez,Paul W. Sternberg,Paul W. Sternberg,Annette M. Dougall,Soraya Gaze,Jason Mulvenna,Javier Sotillo,Shoba Ranganathan,Shoba Ranganathan,Élida Mara Leite Rabelo,Richard K. Wilson,Philip L. Felgner,Jeffrey M. Bethony,John M. Hawdon,Robin B. Gasser,Alex Loukas,Makedonka Mitreva +30 more
TL;DR: Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms.
Journal ArticleDOI
A portrait of the "SCP/TAPS" proteins of eukaryotes--developing a framework for fundamental research and biotechnological outcomes.
Cinzia Cantacessi,Bronwyn E. Campbell,Aline Visser,Peter Geldhof,Matthew J. Nolan,Alasdair J. Nisbet,J. B. Matthews,Alex Loukas,Andreas Hofmann,Domenico Otranto,Paul W. Sternberg,Robin B. Gasser +11 more
TL;DR: A comprehensive, systematic phylogenetic analysis of currently available full-length protein sequence data is undertaken to infer relationships and provide a framework (based on statistical support) for the naming of key SCP/TAPS proteins of eukaryotes, with an emphasis on parasitic helminths.
Journal ArticleDOI
Vaccines to combat the neglected tropical diseases.
Jeffrey M. Bethony,Rhea N. Cole,Xiaoti Guo,Shaden Kamhawi,Marshall W. Lightowlers,Alex Loukas,William A. Petri,Steven G. Reed,Jesus G. Valenzuela,Peter J. Hotez +9 more
TL;DR: The current status of scientific and technical progress in the development of new neglected tropical disease vaccines is reviewed, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities forDevelopment of new vaccines for NTDs.
References
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Journal ArticleDOI
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
Jeffrey M. Bethony,Jeffrey M. Bethony,Simon Brooker,Marco Albonico,Stefan M. Geiger,Stefan M. Geiger,Alex Loukas,David Diemert,Peter J. Hotez +8 more
TL;DR: Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools.
Journal ArticleDOI
A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.
José A. Stoute,Moncef Mohamed Slaoui,D. G. Heppner,P Momin,Kent E. Kester,P Desmons,Bruce T. Wellde,Nathalie Garcon,Urszula Krzych,M Marchand +9 more
TL;DR: A recombinant vaccine based on fusion of the circumsporozoite protein and HBsAg plus a potent adjuvant can protect against experimental challenge with P. falciparum malaria.
Journal ArticleDOI
Cysteine proteases of parasitic organisms
Mohammed Sajid,James H. McKerrow +1 more
TL;DR: In this paper, the authors highlight recent research on the Papain-like and asparaginyl-endopeptidase classes of cysteine proteases and re-examine them in light of the diversity uncovered within parasitic organisms.
Journal ArticleDOI
The global burden of intestinal nematode infections — Fifty years on
TL;DR: Using a mathematical model, it is estimated that approximately 70% of this burden can be prevented in high-prevalence communities by treating schoolchildren alone, and hence this provides a realistic approach for combating these infections in the future.
Book ChapterDOI
Human Hookworm Infection in the 21st Century
TL;DR: This chapter reviews recent advances in the understanding in the biology, immunology, epidemiology, public health significance and control of hookworm, and to look forward to the study of this important parasite in the 21st century.