The extracellular matrix modulates the hallmarks of cancer
Reads0
Chats0
TLDR
It is suggested that the success of cancer prevention and therapy programs requires an intimate understanding of the reciprocal feedback between the evolving extracellular matrix, the tumor cells and its cancer‐associated cellular stroma.Abstract:
The extracellular matrix regulates tissue development and homeostasis, and its dysregulation contributes to neoplastic progression. The extracellular matrix serves not only as the scaffold upon which tissues are organized but provides critical biochemical and biomechanical cues that direct cell growth, survival, migration and differentiation and modulate vascular development and immune function. Thus, while genetic modifications in tumor cells undoubtedly initiate and drive malignancy, cancer progresses within a dynamically evolving extracellular matrix that modulates virtually every behavioral facet of the tumor cells and cancer-associated stromal cells. Hanahan and Weinberg defined the hallmarks of cancer to encompass key biological capabilities that are acquired and essential for the development, growth and dissemination of all human cancers. These capabilities include sustained proliferation, evasion of growth suppression, death resistance, replicative immortality, induced angiogenesis, initiation of invasion, dysregulation of cellular energetics, avoidance of immune destruction and chronic inflammation. Here, we argue that biophysical and biochemical cues from the tumor-associated extracellular matrix influence each of these cancer hallmarks and are therefore critical for malignancy. We suggest that the success of cancer prevention and therapy programs requires an intimate understanding of the reciprocal feedback between the evolving extracellular matrix, the tumor cells and its cancer-associated cellular stroma.read more
Citations
More filters
Journal ArticleDOI
Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application
Shigeo Saito,Chia-Chen Ku,Kenly Wuputra,Jia-Bin Pan,Chang-Shen Lin,Ying Chu Lin,Deng-Chyang Wu,Kazunari K. Yokoyama +7 more
TL;DR: This article provides a review of the most frequently used CSCs and stem cell markers and explains how these analyses are critical for the therapeutic application of drugs and the efficient targeting and prevention of cancer progression.
DissertationDOI
Somatic genome alterations in relation to age in smoking related cancers
TL;DR: Thesis project, which aims to provide real-time information about the “building blocks” of DNA methylation, and its role in cancer and other diseases, is described.
MonographDOI
The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer
TL;DR: A large number of women in Sweden are diagnosed with breast cancer yearly and despite advantages in diagnostics and treatments, there are still gaps in knowledge about the disease and its treatment options.
Journal ArticleDOI
Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.
Michael J Podolsky,Deepti Gupta,Arnold Ha,Ryan Ta,Amin Khalifeh-Soltani,William McKleroy,Ritwik Datta,Dean Sheppard,Kamran Atabai +8 more
TL;DR: The function of cell division cycle 7 kinase (CDC7) is described as a specific suppressor of collagen uptake and it is shown that the genetic or pharmacological inhibition of CDC7 results in increased expression of the collagen endocytic receptor Endo180.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
Journal ArticleDOI
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.