Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Helmut Sies,Vsevolod V. Belousov,Navdeep S. Chandel,Michael J. Davies,Dean P. Jones,Giovanni E. Mann,Michael P. Murphy,Masayuki Yamamoto,Christine C. Winterbourn +8 more
TL;DR: This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H2O2 and O2, and stresses that physiological O2 levels should be maintained in cell culture to better mimic in vivo redox reactions associated with specific cell types.
Journal ArticleDOI
Hormesis and insects: Effects and interactions in agroecosystems.
G. Christopher Cutler,Marcel Amichot,Giovanni Benelli,Raul Narciso C. Guedes,Yanyan Qu,Rachel R. Rix,Farman Ullah,Nicolas Desneux +7 more
TL;DR: In this article , the major ecological niches insects occupy or guilds to which they belong in agroecosystems and how hormesis can manifest within and across these groups are examined.
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Curcumin nanoformulations to combat aging-related diseases.
Maryam Mahjoob,Ursula Stochaj +1 more
TL;DR: A review of different forms of nano-curcumin that have been evaluated in vitro and in vivo to treat or prevent aging-associated health impairments is presented in this article, highlighting outstanding questions and future work that is needed to ensure nano-Curcumin is efficient and safe to lessen the burden of aging-related health problems.
Journal ArticleDOI
Pesticide-Induced Hormesis in Arthropods: Towards Biological Systems
TL;DR: In this paper , a mini-review emphasizes how hormesis may affect species interactions and the broader consequences at the community level to provide further understanding of its eco-evolutionary relevance beyond its short-term practical implications for agriculture production.
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Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
References
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Journal ArticleDOI
Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice: A Potential Mechanism to Prevent Diabetic Nephropathy
Xiao Xing,Chi Zhang,Minglong Shao,Qingyue Tong,Guirong Zhang,Cai Li,Jie Cheng,Shunzi Jin,Jisheng Ma,Guanjun Wang,Xiaokun Li,Lu Cai +11 more
TL;DR: It is found that 75 mGy of X-rays can stimulate Akt signaling pathway and upregulate Nrf2 expression and function in diabetic kidneys, which may explain the prevention of LDR against the diabetic nephropathy.
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Bisphenol A activates the Nrf1/2-antioxidant response element pathway in HEK 293 cells.
Nikolai L. Chepelev,Mutiat I Enikanolaiye,Leonid L. Chepelev,Abdulrahman Almohaisen,Qixuan Chen,Kylie A. Scoggan,Kylie A. Scoggan,Melanie C Coughlan,Xu-Liang Cao,Xiaolei Jin,William G. Willmore +10 more
TL;DR: This study suggests that BPA activates the Nrf1/2-ARE pathway at high (>10 μM) micromolar concentrations, and increases the transactivation activity of ectopic NRF1 and Nrf2 and increased the expression of ARE-target genes ho-1 and nqo1 at high BPA concentrations only.
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Low-dose gamma-ray irradiation induces translocation of Nrf2 into nuclear in mouse macrophage RAW264.7 cells.
TL;DR: The results indicate that low-dose gamma-irradiation induces activation of Nrf2 through ERK1/2-dependent pathways.
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Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity.
TL;DR: The data suggest that preconditioning effects induced by Tg mediate an adaptive response to 6-OHDA-induced cytotoxicity via phosphorylation of eIF2α and activation of the ARE and that Tg enhances antioxidative defenses in SH-SY5Y cells compared with Tm.
Journal ArticleDOI
Does Green Tea Induce Hormesis
Edward J. Calabrese,Aristidis Tsatsakis,Evgenios Agathokleous,James Giordano,Vittorio Calabrese +4 more
TL;DR: The general findings demonstrate EGCG-induced hormetic effects resulting in an enhanced acquired resilience within an adaptive and temporally dependent homeodynamic framework and indicate the need to assess the entire dose-response continuum in order to better define the nature of the dose response, especially in the low-dose zone where such exposures are common in human populations.