Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Helmut Sies,Vsevolod V. Belousov,Navdeep S. Chandel,Michael J. Davies,Dean P. Jones,Giovanni E. Mann,Michael P. Murphy,Masayuki Yamamoto,Christine C. Winterbourn +8 more
TL;DR: This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H2O2 and O2, and stresses that physiological O2 levels should be maintained in cell culture to better mimic in vivo redox reactions associated with specific cell types.
Journal ArticleDOI
Hormesis and insects: Effects and interactions in agroecosystems.
G. Christopher Cutler,Marcel Amichot,Giovanni Benelli,Raul Narciso C. Guedes,Yanyan Qu,Rachel R. Rix,Farman Ullah,Nicolas Desneux +7 more
TL;DR: In this article , the major ecological niches insects occupy or guilds to which they belong in agroecosystems and how hormesis can manifest within and across these groups are examined.
Journal ArticleDOI
Curcumin nanoformulations to combat aging-related diseases.
Maryam Mahjoob,Ursula Stochaj +1 more
TL;DR: A review of different forms of nano-curcumin that have been evaluated in vitro and in vivo to treat or prevent aging-associated health impairments is presented in this article, highlighting outstanding questions and future work that is needed to ensure nano-Curcumin is efficient and safe to lessen the burden of aging-related health problems.
Journal ArticleDOI
Pesticide-Induced Hormesis in Arthropods: Towards Biological Systems
TL;DR: In this paper , a mini-review emphasizes how hormesis may affect species interactions and the broader consequences at the community level to provide further understanding of its eco-evolutionary relevance beyond its short-term practical implications for agriculture production.
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Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
References
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Journal ArticleDOI
Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells.
TL;DR: Results from this reanalysis of high-resolution ARE response data support the hypothesis that nonlinear ARE-mediated adaptive cellular responses to oxidative stress are governed by an ultrasensitive molecular switch.
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The effects of Nrf2 knockout on regulation of benzene-induced mouse hematotoxicity.
Huiyao Li,Daochuan Li,Zhini He,Junling Fan,Qingye Li,Xiaoling Liu,Ping Guo,Haiyan Zhang,Shen Chen,Qiong Li,Rui Zhang,Xiumei Xing,Xiao-Wen Zeng,Aihua Zhang,Huanwen Tang,Guang-Hui Dong,Qing Wang,Yongmei Xiao,Liping Chen,Wen Chen +19 more
TL;DR: Notably, the depletion of Nrf2 triggered the proliferation and differentiation of hematopoietic cells, but induced aberrant morphological changes in periphery erythrocytes and bone marrow cells, implicating the compensatory effects carried on at the expense of induction of dysfunctional blood cells.
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Early antioxidant responses via the concerted activation of NF-κB and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human peripheral blood mononuclear cells.
TL;DR: Reduced oxidative stress in primed PBMCs correlated with greater nuclear translocation of the redox-sensitive transcription factors Nuclear factor kappa B (NF-κB) and Nuclear factor E2-related factor 2 (Nrf2).
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Effect of fluoride on PERK-Nrf2 signaling pathway in mouse ameloblasts.
TL;DR: It is proved that fluoride under certain dose can induce ER stress and promote Nrf2 nuclear import via PERK activation and suggested that antioxidation mechanism mediated by PERK-Nrf2 can alleviate fluoride-induced ER stress effectively.
Journal ArticleDOI
How sodium arsenite improve amyloid β-induced memory deficit?
Ehsan Nassireslami,Parmida Nikbin,Elham Amini,Borna Payandemehr,Fatemeh Shaerzadeh,Fariba Khodagholi,Behnoosh Bonakdar Yazdi,Abbas Kebriaeezadeh,Ghorban Taghizadeh,Mohammad Sharifzadeh +9 more
TL;DR: It seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Aβ-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-κB amount.