Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
TL;DR: In this paper , a review of the effects of isothiocyanates and its application in nano-formulations and the delivery is presented, which suggests that the benefits or risks of using them in combination with known anti-cancer drugs largely depend on the dose and endpoint of interest.
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NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products
TL;DR: Developing novel and safe Nrf2 modulators for skin care may be challenging, new avenues can arise from natural compounds-based molecular modeling and emerging concepts such as epigenetic regulation.
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The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise.
Marcelo Paes de Barros,André Luis Lacerda Bachi,Juliana de Melo Batista dos Santos,Rafael Herling Lambertucci,Rafael Ishihara,Tatiana G. Polotow,Adriana Caldo-Silva,Pedro Afonso Valente,Eef Hogervorst,Guilherme Eustáquio Furtado +9 more
TL;DR: In this paper, a review outlines the various factors associated with unhealthy aging which includes becoming frail and dependent, and discusses the wide variety of molecular, cellular and endocrine mechanisms underlying this process and their interrelationships.
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No clear concerns related to health risks in the European population with low inorganic arsenic exposure (overview)
TL;DR: In this paper , an overview of recent European background inorganic arsenic (iAs) levels and related human health risks is given, with the main aim to summarize and confront the existing concentration data, unresolved low dose-response issues, and methodological approaches hampered by several uncertainties on several levels.
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Rhodiola rosea and Salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection.
TL;DR: In this paper , the biological effects of Rhodiola rosea extracts and one of its major constituents, salidroside, were evaluated for their capacity to induce hormesis/hormetic effects.
References
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Nrf2-Keap1 defines a physiologically important stress response mechanism.
TL;DR: Analysis of keap1-knockout mice provides solid evidence that Keap1 acts as a negative regulator of Nrf2 and as a sensor of xenobiotic and oxidative stresses.
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Nrf2 signaling pathway: Pivotal roles in inflammation.
TL;DR: The members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway are discussed.
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Expression of Nrf2 in Neurodegenerative Diseases
Chenere P. Ramsey,Charles A. Glass,Marshall B. Montgomery,Kathryn A. Lindl,Gillian P. Ritson,Luis A. Chia,Ronald L. Hamilton,Charleen T. Chu,Kelly L. Jordan-Sciutto +8 more
TL;DR: It is suggested that Nrf2-mediated transcription is not induced in neurons in AD despite the presence of oxidative stress, and in PD, nuclear localization of NRF2 is strongly induced, but this response may be insufficient to protect neurons from degeneration.
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When NRF2 Talks, Who's Listening?
TL;DR: This review highlights recent observations on the molecular interactions and their functional consequences between NRF2 and the arylhydrocarbon receptor (AhR), NF-κB, p53, and Notch1 signaling pathways, which provide a multi-tiered, integrated response to chemical stresses.
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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease : Critical role for the astrocyte
Pei Chun Chen,Marcelo R. Vargas,Amar K. Pani,Richard J. Smeyne,Delinda A. Johnson,Yuet Wai Kan,Jeffrey A. Johnson +6 more
TL;DR: Stark results indicate that Nrf2 expression restricted to astrocytes is sufficient to protect against MPTP andAstrocytic modulation of the NRF2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing neuronal death in PD.