Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Helmut Sies,Vsevolod V. Belousov,Navdeep S. Chandel,Michael J. Davies,Dean P. Jones,Giovanni E. Mann,Michael P. Murphy,Masayuki Yamamoto,Christine C. Winterbourn +8 more
TL;DR: This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H2O2 and O2, and stresses that physiological O2 levels should be maintained in cell culture to better mimic in vivo redox reactions associated with specific cell types.
Journal ArticleDOI
Hormesis and insects: Effects and interactions in agroecosystems.
G. Christopher Cutler,Marcel Amichot,Giovanni Benelli,Raul Narciso C. Guedes,Yanyan Qu,Rachel R. Rix,Farman Ullah,Nicolas Desneux +7 more
TL;DR: In this article , the major ecological niches insects occupy or guilds to which they belong in agroecosystems and how hormesis can manifest within and across these groups are examined.
Journal ArticleDOI
Curcumin nanoformulations to combat aging-related diseases.
Maryam Mahjoob,Ursula Stochaj +1 more
TL;DR: A review of different forms of nano-curcumin that have been evaluated in vitro and in vivo to treat or prevent aging-associated health impairments is presented in this article, highlighting outstanding questions and future work that is needed to ensure nano-Curcumin is efficient and safe to lessen the burden of aging-related health problems.
Journal ArticleDOI
Pesticide-Induced Hormesis in Arthropods: Towards Biological Systems
TL;DR: In this paper , a mini-review emphasizes how hormesis may affect species interactions and the broader consequences at the community level to provide further understanding of its eco-evolutionary relevance beyond its short-term practical implications for agriculture production.
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Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
References
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Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway
Kun Shu,Yuelin Zhang +1 more
TL;DR: In this paper, the neuroprotective effect of Protodioscin (Prot) in an in vitro model of ischemia/reperfusion (I/R) and investigate the underlying molecular mechanism.
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Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.
Ming-Xing Zhou,Guo-Hui Li,Bin Sun,Xu Youwei,Ai-Ling Li,Yan-Ru Li,Dong-Mei Ren,Xiao-Ning Wang,Xue-Sen Wen,Hong-Xiang Lou,Tao Shen +10 more
TL;DR: NLD and THD are two novel Nrf2 activators with potential application of preventing acute and chronic oxidative insults in human lung tissue.
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Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Yan-Ru Li,Guo-Hui Li,Ming-Xing Zhou,Lan Xiang,Dong-Mei Ren,Hong-Xiang Lou,Xiao-Ning Wang,Tao Shen +7 more
TL;DR: 7-MBA is a novel isoflavone-type Nrf2 activator displaying potential preventive effect against oxidative damages in human lung epithelial cells.
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Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway.
Guizhen Zheng,Huijuan Ren,Hongqiang Li,Xiuhua Li,Tiancao Dong,Shumin Xu,Yanli Yan,Bingke Sun,Jianwen Bai,Yusheng Li +9 more
TL;DR: The cell study showed that the LBP-induced activation of Nrf2 was dampened in pulmonary microvascular endothelial cells when the AMPK signal was inhibited by siRNA, suggesting that the benefit of LBP on hyperoxia-induced acute lung injury was abolished in NRF2-/- mice.
Journal ArticleDOI
JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2
TL;DR: Investigation revealed that the protective effect of JWA mostly involves regulation of the MEK/PI3K-Nrf2 axis and suggests that JWA may be a novel target for the prevention and treatment of PQ-induced PD.