Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases
Journal ArticleDOI
An updated patent review of Nrf2 activators (2020-present)
TL;DR: A review of Nrf2 activators can be found in this article , where the authors discuss the biological effects of NRF2 and the regulatory mechanism of Kelch-like ECH-associated protein 1-Nrf2-antioxidant response element (Keap1-NRF2-ARE) pathway.
Journal ArticleDOI
Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease
TL;DR: In this paper , the authors analyzed the results obtained in a set of studies carried out in the last years, which describe the neuroprotective, antioxidant and regenerative functions of some naturally occurring antioxidants in experimental models of Parkinson's disease.
Journal ArticleDOI
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
TL;DR: In this paper , the effect of oleanolic acid (OA) on ANIT-induced cholestatic liver injury and the interaction mechanism between NRF2 and FXR signaling pathways in maintaining bile acid homeostasis were investigated.
Book ChapterDOI
Food for Brain Health
Vittorio Calabrese,Angela Trovato,Maria Scuto,Maria Laura Ontario,Francesco Rampulla,Vincenzo Zimbone,Ignazio La Mantia,Valentina Greco,Sebastiano Sciuto,Roberto Crea,Edward J. Calabrese,Giuseppe Dionisio +11 more
TL;DR: In this paper, the authors focused on potential neuroprotective mechanisms of nutrition, in particular dietary polyphenols involved in the activation of vitagenes resulting in improved intracellular antioxidant defense systems against ROS damage leading to degeneration and death with considerable impact on brain health and longevity processes.
References
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Journal ArticleDOI
Nrf2-Keap1 defines a physiologically important stress response mechanism.
TL;DR: Analysis of keap1-knockout mice provides solid evidence that Keap1 acts as a negative regulator of Nrf2 and as a sensor of xenobiotic and oxidative stresses.
Journal ArticleDOI
Nrf2 signaling pathway: Pivotal roles in inflammation.
TL;DR: The members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway are discussed.
Journal ArticleDOI
Expression of Nrf2 in Neurodegenerative Diseases
Chenere P. Ramsey,Charles A. Glass,Marshall B. Montgomery,Kathryn A. Lindl,Gillian P. Ritson,Luis A. Chia,Ronald L. Hamilton,Charleen T. Chu,Kelly L. Jordan-Sciutto +8 more
TL;DR: It is suggested that Nrf2-mediated transcription is not induced in neurons in AD despite the presence of oxidative stress, and in PD, nuclear localization of NRF2 is strongly induced, but this response may be insufficient to protect neurons from degeneration.
Journal ArticleDOI
When NRF2 Talks, Who's Listening?
TL;DR: This review highlights recent observations on the molecular interactions and their functional consequences between NRF2 and the arylhydrocarbon receptor (AhR), NF-κB, p53, and Notch1 signaling pathways, which provide a multi-tiered, integrated response to chemical stresses.
Journal ArticleDOI
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease : Critical role for the astrocyte
Pei Chun Chen,Marcelo R. Vargas,Amar K. Pani,Richard J. Smeyne,Delinda A. Johnson,Yuet Wai Kan,Jeffrey A. Johnson +6 more
TL;DR: Stark results indicate that Nrf2 expression restricted to astrocytes is sufficient to protect against MPTP andAstrocytic modulation of the NRF2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing neuronal death in PD.