Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Helmut Sies,Vsevolod V. Belousov,Navdeep S. Chandel,Michael J. Davies,Dean P. Jones,Giovanni E. Mann,Michael P. Murphy,Masayuki Yamamoto,Christine C. Winterbourn +8 more
TL;DR: This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H2O2 and O2, and stresses that physiological O2 levels should be maintained in cell culture to better mimic in vivo redox reactions associated with specific cell types.
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Hormesis and insects: Effects and interactions in agroecosystems.
G. Christopher Cutler,Marcel Amichot,Giovanni Benelli,Raul Narciso C. Guedes,Yanyan Qu,Rachel R. Rix,Farman Ullah,Nicolas Desneux +7 more
TL;DR: In this article , the major ecological niches insects occupy or guilds to which they belong in agroecosystems and how hormesis can manifest within and across these groups are examined.
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Curcumin nanoformulations to combat aging-related diseases.
Maryam Mahjoob,Ursula Stochaj +1 more
TL;DR: A review of different forms of nano-curcumin that have been evaluated in vitro and in vivo to treat or prevent aging-associated health impairments is presented in this article, highlighting outstanding questions and future work that is needed to ensure nano-Curcumin is efficient and safe to lessen the burden of aging-related health problems.
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Pesticide-Induced Hormesis in Arthropods: Towards Biological Systems
TL;DR: In this paper , a mini-review emphasizes how hormesis may affect species interactions and the broader consequences at the community level to provide further understanding of its eco-evolutionary relevance beyond its short-term practical implications for agriculture production.
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Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
References
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Journal ArticleDOI
Nrf2: friend or foe for chemoprevention?
TL;DR: This review provides a synopsis of KEAP1-NRF2 signaling, compares the impact of genetic versus pharmacologic activation and considers both the attributes and concerns of targeting the pathway in chemoprevention.
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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
TL;DR: The biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases are reviewed and the potential therapeutic opportunities targeting ROS will be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.
Journal Article
Defining hormesis. Commentary. Authors reply
Edward J. Calabrese,L. A. Baldwin,P. M. Chapman,Giovanni Carelli,Ivo Iavicoli,K. T. Kitchin,J. A. Pickrell,F. W. Oehme,A. C. Upton +8 more
TL;DR: Hormesis should be considered an adaptive response characterized by biphasic dose responses of generally similar quantitative features with respect to amplitude and range of the stimulatory response that are either directly induced or the result of compensatory biological processes following an initial disruption in homeostasis.
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"Lest we forget you--methylene blue...".
TL;DR: The history and medical applications of methylene blue are reviewed, with emphasis on recent developments, as a potential treatment of neurodegenerative disorders such as Alzheimer's disease.
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Nrf2‐deficient mice are highly susceptible to cigarette smoke‐induced emphysema
Takashi Iizuka,Yukio Ishii,Ken Itoh,Takumi Kiwamoto,Toru Kimura,Yosuke Matsuno,Yuko Morishima,Ahmed E. Hegab,Shinsuke Homma,Akihiro Nomura,Tohru Sakamoto,Masako Shimura,Aruto Yoshida,Masayuki Yamamoto,Kiyohisa Sekizawa +14 more
TL;DR: Results indicate that Nrf2 protects against the development of emphysema by regulating not only the oxidant/anti‐oxidant balance, but also inflammation and the protease/anti-protease balance.