Journal ArticleDOI
The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Induced Pluripotent Stem Cells and Hormesis
TL;DR: This paper represents the first assessment of agent-induced hormetic dose responses in induced pluripotent stem cells and their derived cells, and compares with hormetic responses in multiple adult and embryonic stem cells.
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Anoxia elicits the strongest stimulatory protective response in insect low-oxygen hormesis
TL;DR: In this paper , the authors summarize the recent advancements in low-oxygen hormesis with a focus on severe hypoxia and anoxia, and present a glimpse at the known mechanism of this type of hormesis.
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Hormesis and embryonic stem cells
TL;DR: In this article , the authors identify and detailed assessment of hormetic dose responses of embryonic stem cells with particular emphasis on cell renewal (proliferation) and differentiation, underlying mechanistic foundations and potential therapeutic implications.
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Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression
Ann-Kathrin Eichelmann,George C. Mayne,George C. Mayne,Karen Chiam,Steven L. Due,Isabell Bastian,Frederike Butz,Tingting Wang,Pamela J. Sykes,Nicholas J. Clemons,David Shi Hao Liu,Michael Michael,Michael Michael,Christos S. Karapetis,Christos S. Karapetis,Richard Hummel,David I. Watson,David I. Watson,Damian J. Hussey,Damian J. Hussey +19 more
TL;DR: In this paper, the role of mutant (mut-) p53 and SLC7A11 in a CRISPR-mediated JH-EsoAd1 TP53 knockout model was investigated.
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Treatment of Early-Stage Alzheimer’s Disease With CT Scans of the Brain: A Case Report
TL;DR: The case of a patient in Massachusetts with early-stage Alzheimer’s disease who was treated with low doses of ionizing radiation to the brain and his impaired conversation, reading, and sense of humor were restored, especially his virtuosic clarinet jazz-playing, suggesting CT scans may have value in treating Alzheimer's patients and restoring, at least temporarily, important aspects of normal life activities.
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Journal ArticleDOI
Nrf2-Keap1 defines a physiologically important stress response mechanism.
TL;DR: Analysis of keap1-knockout mice provides solid evidence that Keap1 acts as a negative regulator of Nrf2 and as a sensor of xenobiotic and oxidative stresses.
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Nrf2 signaling pathway: Pivotal roles in inflammation.
TL;DR: The members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway are discussed.
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Expression of Nrf2 in Neurodegenerative Diseases
Chenere P. Ramsey,Charles A. Glass,Marshall B. Montgomery,Kathryn A. Lindl,Gillian P. Ritson,Luis A. Chia,Ronald L. Hamilton,Charleen T. Chu,Kelly L. Jordan-Sciutto +8 more
TL;DR: It is suggested that Nrf2-mediated transcription is not induced in neurons in AD despite the presence of oxidative stress, and in PD, nuclear localization of NRF2 is strongly induced, but this response may be insufficient to protect neurons from degeneration.
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When NRF2 Talks, Who's Listening?
TL;DR: This review highlights recent observations on the molecular interactions and their functional consequences between NRF2 and the arylhydrocarbon receptor (AhR), NF-κB, p53, and Notch1 signaling pathways, which provide a multi-tiered, integrated response to chemical stresses.
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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease : Critical role for the astrocyte
Pei Chun Chen,Marcelo R. Vargas,Amar K. Pani,Richard J. Smeyne,Delinda A. Johnson,Yuet Wai Kan,Jeffrey A. Johnson +6 more
TL;DR: Stark results indicate that Nrf2 expression restricted to astrocytes is sufficient to protect against MPTP andAstrocytic modulation of the NRF2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing neuronal death in PD.