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The hormetic dose-response mechanism: Nrf2 activation
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TLDR
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses as discussed by the authors.About:
This article is published in Pharmacological Research.The article was published on 2021-03-02. It has received 89 citations till now. The article focuses on the topics: Mechanism (biology).read more
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Helmut Sies,Vsevolod V. Belousov,Navdeep S. Chandel,Michael J. Davies,Dean P. Jones,Giovanni E. Mann,Michael P. Murphy,Masayuki Yamamoto,Christine C. Winterbourn +8 more
TL;DR: This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H2O2 and O2, and stresses that physiological O2 levels should be maintained in cell culture to better mimic in vivo redox reactions associated with specific cell types.
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Hormesis and insects: Effects and interactions in agroecosystems.
G. Christopher Cutler,Marcel Amichot,Giovanni Benelli,Raul Narciso C. Guedes,Yanyan Qu,Rachel R. Rix,Farman Ullah,Nicolas Desneux +7 more
TL;DR: In this article , the major ecological niches insects occupy or guilds to which they belong in agroecosystems and how hormesis can manifest within and across these groups are examined.
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Curcumin nanoformulations to combat aging-related diseases.
Maryam Mahjoob,Ursula Stochaj +1 more
TL;DR: A review of different forms of nano-curcumin that have been evaluated in vitro and in vivo to treat or prevent aging-associated health impairments is presented in this article, highlighting outstanding questions and future work that is needed to ensure nano-Curcumin is efficient and safe to lessen the burden of aging-related health problems.
Journal ArticleDOI
Pesticide-Induced Hormesis in Arthropods: Towards Biological Systems
TL;DR: In this paper , a mini-review emphasizes how hormesis may affect species interactions and the broader consequences at the community level to provide further understanding of its eco-evolutionary relevance beyond its short-term practical implications for agriculture production.
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Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
References
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Journal ArticleDOI
Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.
Chung Ho Leung,Christopher A. Caldarone,Rui Guan,Xiao-Yan Wen,Menachem Ailenberg,Andras Kapus,Andras Kapus,Katalin Szászi,Katalin Szászi,Ori D. Rotstein +9 more
TL;DR: A murine model of S/R is used to investigate the role of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in mediating hepatoprotection and demonstrate the critical role of Nrf2 in the ability of RIC to prevent organ injury after S/ R.
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Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells.
TL;DR: Results suggest that CO released by CORM-2 treatment may have protective effects against oxidative cell death in PD through the potentiation of cellular adaptive survival responses via activation of Nrf2 and upregulation of heme oxygenase-1, leading to increasing antioxidant defense capacity.
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Methylene blue elicits non-genotoxic H2O2 production and protects brain mitochondria from rotenone toxicity
Artem P. Gureev,Ekaterina A. Shaforostova,Denis A. Laver,Victoria G. Khorolskaya,Mikhail Y. Syromyatnikov,Vasily N. Popov +5 more
TL;DR: It is suggested that MB-induced mild oxidative stress does not have genotoxic effect on mitochondrial DNA, and the neuroprotective properties of MB pretreatments after rotenone injection are shown.
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Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells
TL;DR: Results suggested that SC displayed potential application for the prevention and therapy against oxidative stress-induced diseases, and isopimarane-type diterpenoid represents a promising skeleton for developing Nrf2 activators.
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(2S)-5,6,7,3′,4′-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-induced cytotoxicity via activating Nrf2-mediated defense system
Ming-Xing Zhou,Guo-Hui Li,Xue-Yi Wu,Lin Sun,Yan-Ru Li,Wen-Jing Yang,Dong-Mei Ren,Xiao-Ning Wang,Lan Xiang,Hong-Xiang Lou,Tao Shen +10 more
TL;DR: The data demonstrate that PMF is a novel NRF2 activator with potential prevention against oxidative insults, and the diverse pharmacological functions of citrus polymethoxyflavone might be related to their ability of activating Nrf2 pathway.